Gene

iqgap2

ID

ZDB-GENE-030131-2878

Name

IQ motif containing GTPase activating protein 2

Symbol

iqgap2 Nomenclature History

Previous Names

fc20f09
si:ch211-157p10.1
wu:fc20f09

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Involved in glomerular filtration and glomerular visceral epithelial cell development. Is expressed in several structures, including cranial vasculature; gut; pericardial region; pronephros; and sensory system. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqgap2 Human Ortholog

No data available

Associated With iqgap2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000593	RasGAP protein, C-terminal
Domain	IPR001202	WW domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	Calponin homology domain	CH domain superfamily	IQ motif, EF-hand binding site	P-loop containing nucleoside triphosphate hydrolase	RasGAP protein, C-terminal	Ras GTPase-activating domain	Rho GTPase activation protein	WW domain
UniProtKB:A2CE93 InterPro	1680
UniProtKB:F1QAC1 InterPro	1673

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	iqgap2-201 (1) Ensembl	Ensembl	9187 nt	Select Tool ZFIN BLAST
mRNA	iqgap2-202 (1) Ensembl	Havana	5192 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-iqgap2	polyclonal	iqgap2		Rabbit		EUROGENTEC S.A.	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations