Gene

adam17a

ID
ZDB-GENE-030131-2862
Name
ADAM metallopeptidase domain 17a
Symbol
adam17a Nomenclature History
Previous Names
  • fc20b01
  • wu:fc20b01
  • zgc:63886
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adam17a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Inflammatory skin and bowel disease, neonatal, 1 614328
Associated With adam17a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR032029 ADAM17, membrane-proximal domain
Domain IPR034025 ADAM10/ADAM17 catalytic domain
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036436 Disintegrin domain superfamily
Domain Details Per Protein
Protein Length ADAM10/ADAM17 catalytic domain ADAM17, membrane-proximal domain Disintegrin domain Disintegrin domain superfamily Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide
UniProtKB:A0A2R8Q3V6 848
UniProtKB:Q6PFU9 842
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations