Gene

adam17a

ID

ZDB-GENE-030131-2862

Name

ADAM metallopeptidase domain 17a

Symbol

adam17a Nomenclature History

Previous Names

fc20b01
wu:fc20b01
zgc:63886

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam17a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Inflammatory skin and bowel disease, neonatal, 1	614328

Associated With adam17a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR032029	ADAM17, membrane-proximal domain
Domain	IPR034025	ADAM10/ADAM17 catalytic domain
Family	IPR051489	Disintegrin and Metalloproteinase Domain-Containing
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily