Gene
serpinc1
- ID
- ZDB-GENE-030131-264
- Name
- serpin peptidase inhibitor, clade C (antithrombin), member 1
- Symbol
- serpinc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase inhibitor activity. Involved in cellular response to estrogen stimulus and regulation of blood coagulation. Predicted to localize to extracellular space. Used to study disseminated intravascular coagulation. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Is expressed in liver; yolk; and yolk syncytial layer. Orthologous to human SERPINC1 (serpin family C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1051 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Liu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| antithrombin III deficiency | Alliance | Thrombophilia 7 due to antithrombin III deficiency | 613118 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| disseminated intravascular coagulation | serpinc1zf548/zf548 | standard conditions | Liu et al., 2014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AYE3
|
450 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpinc1-201
(1)
|
Ensembl | 2,424 nt |
Interactions and Pathways
No data available
Plasmids
No data available