Gene
serpinc1
- ID
- ZDB-GENE-030131-264
- Name
- serpin peptidase inhibitor, clade C (antithrombin), member 1
- Symbol
- serpinc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within cellular response to estrogen stimulus and regulation of blood coagulation. Predicted to be active in extracellular space. Is expressed in liver; yolk; and yolk syncytial layer. Used to study disseminated intravascular coagulation. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1051 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Liu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| antithrombin III deficiency | Alliance | Thrombophilia 7 due to antithrombin III deficiency | 613118 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| disseminated intravascular coagulation | serpinc1zf548/zf548 | standard conditions | Liu et al., 2014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AYE3
|
450 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpinc1-201
(1)
|
Ensembl | 2,424 nt |
Interactions and Pathways
No data available
Plasmids
No data available