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Gene

serpinc1

ID
ZDB-GENE-030131-264
Name
serpin peptidase inhibitor, clade C (antithrombin), member 1
Symbol
serpinc1 Nomenclature History
Previous Names
  • at3 (1)
  • ATIII (1)
  • antithrombin III (1)
  • wu:fb18f10
  • zgc:92299
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within cellular response to estrogen stimulus and regulation of blood coagulation. Predicted to be active in extracellular space. Is expressed in liver; yolk; and yolk syncytial layer. Used to study disseminated intravascular coagulation. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Liu et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With serpinc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
antithrombin III deficiency Alliance Thrombophilia due to antithrombin III deficiency 613118
Associated With serpinc1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023795 Serpin, conserved site
Domain IPR023796 Serpin domain
Domain IPR033829 Antithrombin-III, serpin domain
Family IPR000215 Serpin family
Family IPR015555 Antithrombin-III
Homologous_superfamily IPR036186 Serpin superfamily
Homologous_superfamily IPR042178 Serpin superfamily, domain 1
Homologous_superfamily IPR042185 Serpin superfamily, domain 2
Domain Details Per Protein
Protein Length Antithrombin-III Antithrombin-III, serpin domain Serpin, conserved site Serpin domain Serpin family Serpin superfamily Serpin superfamily, domain 1 Serpin superfamily, domain 2
UniProtKB:Q8AYE3 450
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations