Gene

prpf19

ID

ZDB-GENE-030131-263

Name

pre-mRNA processing factor 19

Symbol

prpf19 Nomenclature History

Previous Names

prp19
fb18f09
wu:fb18f09
zgc:56158 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Involved in negative regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to localize to Prp19 complex; U2-type catalytic step 1 spliceosome; and catalytic step 2 spliceosome. Orthologous to human PRPF19 (pre-mRNA processing factor 19).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6909798 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prpf19 Human Ortholog

No data available

Associated With prpf19 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR003613	U-box domain
Domain	IPR013915	Pre-mRNA-splicing factor 19
Family	IPR038959	Pre-mRNA-processing factor 19
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	G-protein beta WD-40 repeat	Pre-mRNA-processing factor 19	Pre-mRNA-splicing factor 19	U-box domain	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	Zinc finger, RING/FYVE/PHD-type
UniProtKB:Q7ZV92 InterPro	505

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prpf19-201 (1) Ensembl	Havana	2128 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	prp19-002 (1) Ensembl	Havana	741 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	prp19-003 (1) Ensembl	Havana	776 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations