Gene
hspb8
- ID
- ZDB-GENE-030131-2480
- Name
- heat shock protein b8
- Symbol
- hspb8 Nomenclature History
- Previous Names
-
- fc09c11
- wu:fc04b04
- wu:fc09c11
- zgc:64202
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein. Predicted to be part of chaperone complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cephalic musculature; immature eye; midbrain hindbrain boundary neural rod; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and distal hereditary motor neuronopathy type 2A. Orthologous to human HSPB8 (heat shock protein family B (small) member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant distal hereditary motor neuronopathy 2 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 2 | 158590 |
| Charcot-Marie-Tooth disease axonal type 2L | Alliance | Charcot-Marie-Tooth disease, axonal, type 2L | 608673 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002068 | Alpha crystallin/Hsp20 domain |
| Domain | IPR042790 | Heat shock protein beta-8, alpha-crystallin domain (ACD) |
| Family | IPR001436 | Alpha crystallin/Small heat shock protein, animal type |
| Family | IPR043254 | Heat shock protein beta-8 |
| Homologous_superfamily | IPR008978 | HSP20-like chaperone |
Domain Details Per Protein
| Protein | Length | Alpha crystallin/Hsp20 domain | Alpha crystallin/Small heat shock protein, animal type | Heat shock protein beta-8 | Heat shock protein beta-8, alpha-crystallin domain (ACD) | HSP20-like chaperone |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6PFS1
|
216 |
Interactions and Pathways
No data available
Plasmids