Gene

dbr1

ID

ZDB-GENE-030131-2466

Name

debranching RNA lariats 1

Symbol

dbr1 Nomenclature History

Previous Names

wu:fc08f08
zgc:63930

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable RNA lariat debranching enzyme activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63930 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dbr1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Xerosis and growth failure with immune and pulmonary dysfunction syndrome	620510
		{Encephalitis, acute, infection (viral)-induced, susceptibility to, 11}	619441

Associated With dbr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type
Domain	IPR007708	Lariat debranching enzyme, C-terminal
Domain	IPR041816	Lariat debranching enzyme, N-terminal metallophosphatase domain
Homologous_superfamily	IPR029052	Metallo-dependent phosphatase-like