ZFIN is now using GRCz12tu for Genomic Data
Gene
top2a
- ID
- ZDB-GENE-030131-2453
- Name
- DNA topoisomerase II alpha
- Symbol
- top2a Nomenclature History
- Previous Names
-
- fc08c07
- wu:fc08c07
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Acts upstream of or within animal organ regeneration and chromosome segregation. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; eye; midbrain; neural tube; and pectoral fin. Orthologous to human TOP2A (DNA topoisomerase II alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DNA topoisomerase II, resistance to inhibition of, by amsacrine |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018522 | DNA topoisomerase, type IIA, conserved site |
| Domain | IPR002205 | DNA topoisomerase, type IIA, domain A |
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR006171 | TOPRIM domain |
| Domain | IPR012542 | DTHCT |
| Domain | IPR013506 | DNA topoisomerase, type IIA, subunit B, domain 2 |
| Domain | IPR031660 | C-terminal associated domain of TOPRIM |
| Domain | IPR034157 | DNA topoisomerase 2, TOPRIM domain |
| Family | IPR001154 | DNA topoisomerase II, eukaryotic-type |
| Family | IPR001241 | DNA topoisomerase, type IIA |
| Family | IPR050634 | DNA Topoisomerase II |
| Homologous_superfamily | IPR013757 | DNA topoisomerase, type IIA, alpha-helical domain superfamily |
| Homologous_superfamily | IPR013758 | DNA topoisomerase, type IIA, domain A, alpha-beta |
| Homologous_superfamily | IPR013759 | DNA topoisomerase, type IIA, subunit B, C-terminal |
| Homologous_superfamily | IPR013760 | DNA topoisomerase, type IIA-like domain superfamily |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal associated domain of TOPRIM | DNA topoisomerase 2, TOPRIM domain | DNA Topoisomerase II | DNA topoisomerase II, eukaryotic-type | DNA topoisomerase, type IIA | DNA topoisomerase, type IIA, alpha-helical domain superfamily | DNA topoisomerase, type IIA, conserved site | DNA topoisomerase, type IIA, domain A | DNA topoisomerase, type IIA, domain A, alpha-beta | DNA topoisomerase, type IIA-like domain superfamily | DNA topoisomerase, type IIA, subunit B, C-terminal | DNA topoisomerase, type IIA, subunit B, domain 2 | DTHCT | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | TOPRIM domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IUF0 | InterPro | 1570 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers