Gene
pou2f1b
- ID
- ZDB-GENE-030131-2422
- Name
- POU class 2 homeobox 1b
- Symbol
- pou2f1b Nomenclature History
- Previous Names
-
- fc07d06
- wu:fc07d06
- zgc:158360
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in telencephalon. Orthologous to human POU2F1 (POU class 2 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029588Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa34687 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41470 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR000327 | POU-specific domain |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR013847 | POU domain |
| Domain | IPR045703 | POU domain, class 2, transcription factor 1, C-terminal |
| Family | IPR000972 | Octamer-binding transcription factor |
| Family | IPR050255 | POU domain transcription factor |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR010982 | Lambda repressor-like, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily | Octamer-binding transcription factor | POU domain | POU domain, class 2, transcription factor 1, C-terminal | POU domain transcription factor | POU-specific domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AW75 | InterPro | 695 | |||||||||
| UniProtKB:A0A8M2BFA3 | InterPro | 701 | |||||||||
| UniProtKB:A0A8M2BF93 | InterPro | 680 | |||||||||
| UniProtKB:A0A8M3B2T2 | InterPro | 698 | |||||||||
| UniProtKB:A0A8M2BFA0 | InterPro | 702 | |||||||||
| UniProtKB:A0A8M6Z0V0 | InterPro | 701 | |||||||||
| UniProtKB:A4IFW4 | InterPro | 676 | |||||||||
| UniProtKB:A0A8M2BFW2 | InterPro | 699 | |||||||||
| UniProtKB:A0A8M6Z2I0 | InterPro | 694 | |||||||||
| UniProtKB:A0A8M2BF85 | InterPro | 698 | |||||||||
| UniProtKB:A0AB32TUD0 | InterPro | 701 | |||||||||
| UniProtKB:A0AB32TUD6 | InterPro | 701 | |||||||||
| UniProtKB:A0AB32TVN5 | InterPro | 677 | |||||||||
| UniProtKB:A0AB32TXP6 | InterPro | 698 | |||||||||
| UniProtKB:A0AB32TZF6 | InterPro | 680 | |||||||||
| UniProtKB:A0AB32U124 | InterPro | 702 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pou2f1b-201
(1)
|
Ensembl | 5,095 nt | ||
| mRNA |
pou2f1b-202
(1)
|
Ensembl | 1,881 nt | ||
| mRNA |
pou2f1b-203
(1)
|
Ensembl | 5,100 nt | ||
| mRNA |
pou2f1b-204
(1)
|
Ensembl | 966 nt | ||
| mRNA |
pou2f1b-205
(1)
|
Ensembl | 129 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218D20 | ZFIN Curated Data | |
| Encodes | EST | fc07d06 | ||
| Encodes | cDNA | MGC:158360 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001089329 (1) | 5138 nt | ||
| Genomic | GenBank:BX294189 (1) | 194025 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFA0 (1) | 702 aa |
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Gasanov, E.V., Jędrychowska, J., Kuźnicki, J., Korzh, V. (2021) Evolutionary context can clarify gene names: Teleosts as a case study. BioEssays : news and reviews in molecular, cellular and developmental biology. 43(6):e2000258
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Yoder, J.A., Orcutt, T.M., Traver, D., and Litman, G.W. (2007) Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors. Gene. 401(1-2):154-164
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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