Gene
f11r.1
- ID
- ZDB-GENE-030131-2416
- Name
- F11 receptor, tandem duplicate 1
- Symbol
- f11r.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables protein heterodimerization activity. Acts upstream of or within hematopoietic or lymphoid organ development; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to be located in plasma membrane. Predicted to be active in bicellular tight junction. Is expressed in several structures, including EVL; digestive system; integument; renal system; and sensory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103642 (20 images)
- IMAGE:7158623 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sd43 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-f11r.1 | Kondo et al., 2023 | |
| MO1-f11r.1 | N/A | (2) |
| MO2-f11r.1 | N/A | Kobayashi et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Junctional adhesion molecule A |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I72 | InterPro | 292 | |||||||
| UniProtKB:A0AB32TRK8 | InterPro | 294 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
f11r.1-201
(1)
|
Ensembl | 1,749 nt | ||
| ncRNA |
f11r.1-002
(1)
|
Ensembl | 849 nt | ||
| ncRNA |
f11r.1-003
(1)
|
Ensembl | 764 nt |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-99I6 | ZFIN Curated Data | |
| Encodes | EST | fc07c05 | ||
| Encodes | EST | IMAGE:7158623 | Thisse et al., 2004 | |
| Encodes | cDNA | cssl:d121 | Bushell et al., 2007 | |
| Encodes | cDNA | cssl:d216 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:103642 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191226 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004667 (1) | 1392 nt | ||
| Genomic | GenBank:BX510918 (1) | 199447 nt | ||
| Polypeptide | UniProtKB:A0AB32TRK8 (1) | 294 aa |
- Xie, C., Zheng, N., Li, M., Zhang, Z., Huang, D., Xiao, M., Chen, D., He, C., Zuo, Z., Chen, X. (2024) Comparative Analysis of Therapeutic Efficacy and Adverse Reactions among Various Thrombolytic Agents. Toxics. 12(7):
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Yang, R., Zhan, M., Guo, M., Yuan, H., Wang, Y., Zhang, Y., Zhang, W., Chen, S., de The, H., Chen, Z., Zhou, J., Zhu, J. (2020) Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway. Cell death and differentiation. 28(1):170-183
- Bruch-Bertani, J.P., Uribe-Cruz, C., Pasqualotto, A., Longo, L., Ayres, R., Bortolin Beskow, C., Luis Barth, A., Lima-Morales, D., Meurer, F., Tayguara, G., Guerreiro, S., da Silveira, T.R., Álvares-da-Silva, M.R., Dall'Alba, V. (2019) Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish. Journal of the American College of Nutrition. 39(2):163-170
- Xu, P.P., Sun, Y.F., Fang, Y., Song, Q., Yan, Z.X., Chen, Y., Jiang, X.F., Fei, X.C., Zhao, Y., Leboeuf, C., Li, B., Wang, C.F., Janin, A., Wang, L., Zhao, W.L. (2017) JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide. Scientific Reports. 7:7433
- Pillay, L.M., Mackowetzky, K.J., Widen, S.A., Waskiewicz, A.J. (2016) Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation. PLoS One. 11:e0166040
- Kobayashi, I., Kobayashi-Sun, J., Kim, A.D., Pouget, C., Fujita, N., Suda, T., Traver, D. (2014) Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 512(7514):319-23
- Aanes, H., Ostrup, O., Andersen, I.S., Moen, L.F., Mathavan, S., Collas, P., and Alestrom, P. (2013) Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. BMC Genomics. 14(1):331
- Huang, L., Wang, C., Zhang, Y., Li, J., Zhong, Y., Zhou, Y., Chen, Y., and Zuo, Z. (2012) Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos. Chemosphere. 87(4):369-375
- Powell, G.T., and Wright, G.J. (2012) Genomic organisation, embryonic expression and biochemical interactions of the zebrafish junctional adhesion molecule family of receptors. PLoS One. 7(7):e40810
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