Gene

cav1

ID
ZDB-GENE-030131-2415
Name
caveolin 1
Symbol
cav1 Nomenclature History
Previous Names
  • wu:fc07c04
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Exhibits beta-catenin binding activity. Involved in several processes, including animal organ development; regionalization; and regulation of defense response. Predicted to colocalize with caveola; focal adhesion; and sarcolemma. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Is expressed in several structures, including cardiovascular system; ectoderm; integument; lateral line system; and tail bud. Orthologous to human CAV1 (caveolin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cav1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital generalized lipodystrophy type 3 Alliance Lipodystrophy, congenital generalized, type 3 612526
primary pulmonary hypertension Alliance Pulmonary hypertension, primary, 3 615343
Lipodystrophy, familial partial, type 7 606721
Associated With cav1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018361 Caveolin, conserved site
Family IPR001612 Caveolin
Domain Details Per Protein
Protein Length Caveolin Caveolin, conserved site
UniProtKB:Q6YLH9 181
UniProtKB:Q6YLH8 148
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cav1-201 (1) Ensembl 3,830 nt
mRNA cav1-202 (1) Ensembl 1,582 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations