Gene

vkorc1

ID
ZDB-GENE-030131-2286
Name
vitamin K epoxide reductase complex, subunit 1
Symbol
vkorc1 Nomenclature History
Previous Names
  • fc03a11
  • si:dkey-32n7.10
  • wu:fc03a11 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have vitamin-K-epoxide reductase (warfarin-sensitive) activity. Predicted to be involved in blood coagulation; peptidyl-glutamic acid carboxylation; and vitamin K metabolic process. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Is expressed in head. Human ortholog(s) of this gene implicated in warfarin resistance. Orthologous to human VKORC1 (vitamin K epoxide reductase complex subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vkorc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined deficiency of vitamin K-dependent clotting factors 2 Alliance Vitamin K-dependent clotting factors, combined deficiency of, 2 607473
warfarin resistance Alliance Warfarin resistance 122700
Associated With vkorc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR012932 Vitamin K epoxide reductase
Family IPR042406 Vitamin K epoxide reductase complex subunit 1
Homologous_superfamily IPR038354 VKOR domain superfamily
Domain Details Per Protein
Protein Length Vitamin K epoxide reductase Vitamin K epoxide reductase complex subunit 1 VKOR domain superfamily
UniProtKB:E7F6X2 171
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA vkorc1-201 (1) Ensembl 863 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations