Gene
bnip3la
- ID
- ZDB-GENE-030131-2283
- Name
- BCL2 interacting protein 3 like a
- Symbol
- bnip3la Nomenclature History
- Previous Names
-
- bnip3l2
- Nix (1)
- wu:fb52b03
- wu:fc02h04
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable identical protein binding activity. Predicted to be involved in defense response to virus; mitochondrial outer membrane permeabilization; and regulation of programmed cell death. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane and mitochondrial envelope. Predicted to be active in endoplasmic reticulum; mitochondrial outer membrane; and nuclear envelope. Orthologous to human BNIP3L (BCL2 interacting protein 3 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa41111 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010548 | BNIP3 |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | BNIP3 |
|---|---|---|---|
| UniProtKB:Q5VK49 | InterPro | 233 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bnip3la-201
(1)
|
Ensembl | 881 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-112N4 | ZFIN Curated Data | |
| Contains | SNP | rs3728135 | ZFIN Curated Data | |
| Contains | SNP | rs3728136 | ZFIN Curated Data | |
| Contains | SNP | rs3728137 | ZFIN Curated Data | |
| Encodes | EST | fb52b03 | ZFIN Curated Data | |
| Encodes | EST | fc02h04 | ||
| Encodes | cDNA | MGC:195261 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195284 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001012242 (1) | 881 nt | ||
| Genomic | GenBank:CU929046 (2) | 123957 nt | ||
| Polypeptide | UniProtKB:Q5VK49 (1) | 233 aa |
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Wrighton, P.J., Shwartz, A., Heo, J.M., Quenzer, E.D., LaBella, K.A., Harper, J.W., Goessling, W. (2021) Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy. Journal of Cell Science. 134(4):
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
- Zhao, C., Wang, M., Jia, Z., Li, E., Zhao, X., Li, F., Lin, R. (2019) Similar hepatotoxicity response induced by Rhizoma Paridis in zebrafish larvae, cell and rat. Journal of ethnopharmacology. 250:112440
- Pan, Y.X., Luo, Z., Zhuo, M.Q., Wei, C.C., Chen, G.H., Song, Y.F. (2018) Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 199:12-20
- Wang, S., Ji, D., Yang, Q., Li, M., Ma, Z., Zhang, S., Li, H. (2018) NEFLb impairs early nervous system development via regulation of neuron apoptosis in zebrafish. Journal of Cellular Physiology. 234(7):11208-11218
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Chu, F.I., Ho, Y., Huang, C.J., and Tzou, D.L. (2007) 1H, 13C and 15N resonance assignments for proapoptotic protein Nix (residue 1 approximately 156) from Danio rerio. Biomolecular NMR assignments. 1(1):29-31
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