Gene
metap2b
- ID
- ZDB-GENE-030131-2172
- Name
- methionyl aminopeptidase 2b
- Symbol
- metap2b Nomenclature History
- Previous Names
-
- metap2
- wu:fb98h06
- zgc:66250
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Acts upstream of or within Wnt signaling pathway; definitive hemopoiesis; and hematopoietic stem cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart tube; hematopoietic system; pronephric duct; and trunk. Orthologous to human METAP2 (methionyl aminopeptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159348 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018349 | Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site |
| Domain | IPR000994 | Peptidase M24 |
| Family | IPR001714 | Peptidase M24, methionine aminopeptidase |
| Family | IPR002468 | Peptidase M24A, methionine aminopeptidase, subfamily 2 |
| Family | IPR050247 | Methionine Aminopeptidase Type 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Creatinase/aminopeptidase-like | Methionine Aminopeptidase Type 2 | Peptidase M24 | Peptidase M24A, methionine aminopeptidase, subfamily 2 | Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site | Peptidase M24, methionine aminopeptidase | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXK1 | InterPro | 476 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
metap2b-201
(1)
|
Ensembl | 3,008 nt | ||
| ncRNA |
ottdart00000062074
(1)
|
Ensembl | 784 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-340G20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-112D9 | ZFIN Curated Data | |
| Encodes | EST | fb98h06 | ||
| Encodes | EST | IMAGE:7159348 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66250 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199640 (1) | 2462 nt | ||
| Genomic | GenBank:CU184832 (1) | 187294 nt | ||
| Polypeptide | UniProtKB:Q7SXK1 (1) | 476 aa |
- Ma, A.C., Fung, T.K., Lin, R.H., Chung, M.I., Yang, D., Ekker, S.C., and Leung, A.Y. (2011) Methionine aminopeptidase 2 is required for HSC initiation and proliferation. Blood. 118(20):5448-57
- Zhang, Y., Yeh, J.R., Mara, A., Ju, R., Hines, J.F., Cirone, P., Griesbach, H.L., Schneider, I., Slusarski, D.C., Holley, S.A., and Crews, C.M. (2006) A chemical and genetic approach to the mode of action of fumagillin. Chemistry & Biology. 13(9):1001-1009
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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