Gene

apoc2

ID

ZDB-GENE-030131-2168

Name

apolipoprotein C-II

Symbol

apoc2 Nomenclature History

Previous Names

fb71a04
fb98g08
wu:fb52e03
wu:fb71a04
wu:fb98g08

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have enzyme activator activity. Involved in definitive hemopoiesis and lipoprotein catabolic process. Predicted to localize to chylomicron. Used to study familial hyperlipidemia; familial lipoprotein lipase deficiency; and hyperlipoproteinemia type IV. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Is expressed in intestine; liver; pancreas; and yolk. Orthologous to human APOC2 (apolipoprotein C2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apoc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial apolipoprotein C-II deficiency	Alliance	Hyperlipoproteinemia, type Ib	207750

Associated With apoc2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
familial hyperlipidemia	apoc2^sd38/sd38	standard conditions	Liu et al., 2015
familial lipoprotein lipase deficiency	apoc2^sd38/sd38 (AB)	standard conditions	Liu et al., 2017
hyperlipoproteinemia type IV	apoc2^sd38/sd38	standard conditions	Liu et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008019	Apolipoprotein C-II
Homologous_superfamily	IPR023121	ApoC-II domain superfamily

Domain Details Per Protein

Protein	Length	ApoC-II domain superfamily	Apolipoprotein C-II
UniProtKB:E9QEQ1 InterPro	100

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	apoc2-202 (1) Ensembl	Ensembl	798 nt	Select Tool
mRNA	apoc2-203 (1) Ensembl	Ensembl	5,174 nt	Select Tool ZFIN BLAST
ncRNA	apoc2-002 (1) Ensembl	Ensembl	534 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations