ZFIN is now using GRCz12tu for Genomic Data

Gene

apoc2

ID

ZDB-GENE-030131-2168

Name

apolipoprotein C-II

Symbol

apoc2 Nomenclature History

Previous Names

fb71a04
fb98g08
wu:fb52e03
wu:fb71a04
wu:fb98g08

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable phospholipase activator activity and phospholipase binding activity. Acts upstream of or within definitive hemopoiesis; lipid metabolic process; and lipoprotein catabolic process. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in intestine; liver; pancreas; and yolk. Used to study familial hyperlipidemia; familial lipoprotein lipase deficiency; and hyperlipoproteinemia type IV. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 20 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apoc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial apolipoprotein C-II deficiency	Alliance	Hyperlipoproteinemia, type Ib	207750

Associated With apoc2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
familial hyperlipidemia	apoc2^sd38/sd38	standard conditions	Liu et al., 2015
familial lipoprotein lipase deficiency	apoc2^sd38/sd38 (AB)	standard conditions	Liu et al., 2017
hyperlipoproteinemia type IV	apoc2^sd38/sd38	standard conditions	Liu et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008019	Apolipoprotein C-II
Homologous_superfamily	IPR023121	ApoC-II domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	ApoC-II domain superfamily	Apolipoprotein C-II
UniProtKB:E9QEQ1	InterPro	100

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	apoc2-202 (1) Ensembl	Ensembl	798 nt	Select Tool ZFIN BLAST
mRNA	apoc2-203 (1) Ensembl	Ensembl	5,174 nt	Select Tool ZFIN BLAST
ncRNA	apoc2-002 (1) Ensembl	Ensembl	534 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations