Gene
ogdha
- ID
- ZDB-GENE-030131-2143
- Name
- oxoglutarate dehydrogenase a
- Symbol
- ogdha Nomenclature History
- Previous Names
-
- ogdh
- im:7045267
- wu:fa06d01
- wu:fb98a04
- zgc:73296
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Acts upstream of or within heart contraction. Predicted to be located in nucleus. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including immature eye; lens; mesoderm; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in oxoglutarate dehydrogenase deficiency. Orthologous to human OGDH (oxoglutarate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73296 (11 images)
- IMAGE:7146762 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oxoglutarate dehydrogenase deficiency | Alliance | Oxoglutarate dehydrogenase deficiency | 203740 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001017 | Dehydrogenase, E1 component |
| Domain | IPR005475 | Transketolase-like, pyrimidine-binding domain |
| Domain | IPR031717 | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal |
| Domain | IPR032106 | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain |
| Family | IPR011603 | 2-oxoglutarate dehydrogenase E1 component |
| Homologous_superfamily | IPR029061 | Thiamin diphosphate-binding fold |
| Homologous_superfamily | IPR042179 | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | 2-oxoglutarate dehydrogenase E1 component | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain | Dehydrogenase, E1 component | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily | Thiamin diphosphate-binding fold | Transketolase-like, pyrimidine-binding domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BJT5
|
1054 | |||||||
|
UniProtKB:B8JI08
|
1022 | |||||||
|
UniProtKB:F1Q5B8
|
1019 | |||||||
|
UniProtKB:A0A0R4IP01
|
1022 | |||||||
|
UniProtKB:A0A8M3AVG6
|
1037 |
Interactions and Pathways
No data available
Plasmids
No data available