Gene

setd2

ID
ZDB-GENE-030131-2140
Name
SET domain containing 2, histone lysine methyltransferase
Symbol
setd2 Nomenclature History
Previous Names
  • fb97h09
  • wu:fb97h09 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have histone methyltransferase activity (H3-K36 specific). Predicted to be involved in histone H3-K36 trimethylation and regulation of transcription, DNA-templated. Predicted to localize to chromosome and nucleus. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Sun et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With setd2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Luscan-Lumish syndrome 616831
Associated With setd2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001202 WW domain
Domain IPR001214 SET domain
Domain IPR003616 Post-SET domain
Domain IPR006560 AWS domain
Domain IPR013257 Set2 Rpb1 interacting domain
Family IPR042294 Histone-lysine N-methyltransferase SETD2, animal
Homologous_superfamily IPR036020 WW domain superfamily
Homologous_superfamily IPR038190 Set2 Rpb1 interacting domain superfamily
Domain Details Per Protein
Protein Length AWS domain Histone-lysine N-methyltransferase SETD2, animal Post-SET domain Set2 Rpb1 interacting domain Set2 Rpb1 interacting domain superfamily SET domain WW domain WW domain superfamily
UniProtKB:A0A2R8Q6N6 2650
UniProtKB:A5XBP8 175
UniProtKB:Q071D9 369
UniProtKB:A0A2R8Q1Y5 2694
UniProtKB:A0A2R8QDW6 2735
UniProtKB:F1QJI9 2737
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations