Gene
ndnf
- ID
- ZDB-GENE-030131-207
- Name
- neuron-derived neurotrophic factor
- Symbol
- ndnf Nomenclature History
- Previous Names
-
- wu:fb16h09
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity. Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus. Acts upstream of or within embryonic neurocranium morphogenesis. Predicted to be located in extracellular region. Is expressed in central nervous system; cranial ganglion; hypochord; somite; and stomodeum. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Melvin et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37595 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hypogonadotropic hypogonadism 25 with anosmia | 618841 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Neuron-derived neurotrophic factor, first Fn(III) domain | Neuron-derived neurotrophic factor, N-terminal domain | Protein NDNF | Protein NDNF, C-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A9V7 | InterPro | 574 | |||||||
| UniProtKB:F1QPX0 | InterPro | 574 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Messina, A., Pulli, K., Santini, S., Acierno, J., Känsäkoski, J., Cassatella, D., Xu, C., Casoni, F., Malone, S.A., Ternier, G., Conte, D., Sidis, Y., Tommiska, J., Vaaralahti, K., Dwyer, A., Gothilf, Y., Merlo, G.R., Santoni, F., Niederländer, N.J., Giacobini, P., Raivio, T., Pitteloud, N. (2019) Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. American journal of human genetics. 106(1):58-70
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Melvin, V.S., Feng, W., Hernandez-Lagunas, L., Artinger, K.B., and Williams, T. (2013) A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(7):817-31
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