Gene
hdlbpa
- ID
- ZDB-GENE-030131-2032
- Name
- high density lipoprotein binding protein a
- Symbol
- hdlbpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within cellular response to estrogen stimulus. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; immature eye; and pectoral fin. Orthologous to human HDLBP (high density lipoprotein binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb591 (19 images)
- cb811 (19 images)
- IMAGE:7140982 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7582 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa14220 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33870 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40694 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab313 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | K Homology domain | K Homology domain, type 1 | K Homology domain, type 1 superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q7ZU44 | InterPro | 1208 | |||
| UniProtKB:A0A8M2BDG6 | InterPro | 1272 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hdlbpa-201
(1)
|
Ensembl | 5,109 nt | ||
| mRNA |
hdlbpa-203
(1)
|
Ensembl | 1,495 nt | ||
| ncRNA |
hdlbpa-004
(1)
|
Ensembl | 823 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-87O21 | ZFIN Curated Data | |
| Encodes | EST | cb591 | Thisse et al., 2001 | |
| Encodes | EST | cb811 | Thisse et al., 2001 | |
| Encodes | EST | fb36d01 | ZFIN Curated Data | |
| Encodes | EST | fb92e10 | Rauch et al., 2003 | |
| Encodes | EST | fb94h08 | ||
| Encodes | EST | fc23d06 | ZFIN Curated Data | |
| Encodes | EST | fc75h07 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140982 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55613 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201474 (1) | 5124 nt | ||
| Genomic | GenBank:BX957353 (2) | 186825 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDG6 (1) | 1272 aa |
- Wang, Y., Pan, Y., Hou, M., Luo, R., He, J., Lin, F., Xia, X., Li, P., He, C., He, P., Cheng, S., Song, Z. (2023) Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115736115736
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
- Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121
- Knoll-Gellida, A., Andre, M., Gattegno, T., Forgue, J., Admon, A., and Babin, P.J. (2006) Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals. BMC Genomics. 7(1):46
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Chen, J.Y., Chen, J.C., and Wu, J.L. (2003) Molecular cloning and functional analysis of zebrafish high-density lipoprotein-binding protein. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 136(1):117-130
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Ton, C., Hwang, D.M., Dempsey, A.A., Tang, H.C., Yoon, J., Lim, M., Mably, J.D., Fishman, M.C., and Liew, C.C. (2000) Identification, characterization, and mapping of expressed sequence tags from an embryonic zebrafish heart cDNA library. Genome research. 10(12):1915-1927
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