Gene
rpl10a
- ID
- ZDB-GENE-030131-2025
- Name
- ribosomal protein L10a
- Symbol
- rpl10a Nomenclature History
- Previous Names
-
- wu:fb94f08
- zgc:73082
- zgc:86881
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within T cell differentiation in thymus; chordate embryonic development; and hemoglobin biosynthetic process. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Orthologous to human RPL10A (ribosomal protein L10a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73082 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rpl10a | Palasin et al., 2019 | |
| MO1-rpl10a | N/A | Palasin et al., 2019 |
| MO2-rpl10a | N/A | Palasin et al., 2019 |
| MO3-rpl10a | N/A | Lawir et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023673 | Large ribosomal subunit protein uL1, conserved site |
| Family | IPR002143 | Large ribosomal subunit protein uL1 |
| Family | IPR028364 | Ribosomal protein uL1/ribosomal biogenesis protein |
| Family | IPR050257 | Large ribosomal subunit protein eL8/uL1-like |
| Homologous_superfamily | IPR016095 | Large ribosomal subunit protein uL1, 3-layer alpha/beta-sandwich domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Large ribosomal subunit protein eL8/uL1-like | Large ribosomal subunit protein uL1 | Large ribosomal subunit protein uL1, 3-layer alpha/beta-sandwich domain | Large ribosomal subunit protein uL1, conserved site | Ribosomal protein uL1-like | Ribosomal protein uL1/ribosomal biogenesis protein |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QDK8 | InterPro | 133 | ||||||
| UniProtKB:Q6PC69 | InterPro | 216 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
rpl10a-203
(1)
|
Ensembl | 825 nt | ||
| mRNA |
rpl10a-201
(1)
|
Ensembl | 746 nt | ||
| ncRNA |
rpl10a-002
(1)
|
Ensembl | 920 nt | ||
| ncRNA |
rpl10a-003
(1)
|
Ensembl | 910 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(fabp10a:EGFP-rpl10a) |
|
| 1 | de Oliveira et al., 2020 | |
| Tg(actc1b:AVI-EGFP-rpl10a) |
| 1 | (3) | ||
| Tg(atoh7:rpl10a-GFP) |
|
| 1 | Hörnberg et al., 2016 | |
| Tg(fabp10a:EGFP-rpl10a) |
|
| 1 | (5) | |
| Tg(krt18a.1:EGFP-rpl10a) |
|
| 1 | (6) | |
| Tg(myl7:EGFP-rpl10a) |
|
| 1 | (4) | |
| Tg(myo6b:GFP-p2A-rpl10a) |
| 1 | (4) | ||
| Tg(Tru.Tyrp1:EGFP-rpl10a) |
|
| 1 | (2) | |
| Tg(Xla.Eef1a1:EGFP-rpl10a) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-237C6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-163L21 | ZFIN Curated Data | |
| Encodes | EST | fb94f08 | ||
| Encodes | cDNA | MGC:73082 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86881 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199636 (1) | 746 nt | ||
| Genomic | GenBank:AL929282 (2) | 131005 nt | ||
| Polypeptide | UniProtKB:Q6PC69 (1) | 216 aa |
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Zhao, C., Lancman, J.J., Yang, Y., Gates, K.P., Cao, D., Barske, L., Matalonga, J., Pan, X., He, J., Graves, A., Huisken, J., Chen, C., Dong, P.D.S. (2021) Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome. Hepatology (Baltimore, Md.). 75(3):567-583
- de Oliveira, S., Houseright, R.A., Korte, B.G., Huttenlocher, A. (2020) DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma. Disease models & mechanisms. 13(4):
- Lawir, D.F., Sikora, K., O'Meara, C.P., Schorpp, M., Boehm, T. (2020) Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Proceedings of the National Academy of Sciences of the United States of America. 117(27):15799-15808
- Ohta, S., Ji, Y.R., Martin, D., Wu, D.K. (2020) Emx2 regulates hair cell rearrangement but not positional identity within neuromasts. eLIFE. 9:
- Zhao, X., Lorent, K., Escobar-Zarate, D., Rajagopalan, R., Loomes, K.M., Gillespie, K., Mesaros, C., Estrada, M.A., Blair, I., Winkler, J.D., Spinner, N.B., Devoto, M., Pack, M. (2020) Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia. Gastroenterology. 159(3):1068-1084.e2
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Palasin, K., Uechi, T., Yoshihama, M., Srisowanna, N., Choijookhuu, N., Hishikawa, Y., Kenmochi, N., Chotigeat, W. (2019) Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a. Scientific Reports. 9:18130
- Jin, Y.N., Schlueter, P.J., Jurisch-Yaksi, N., Lam, P.Y., Jin, S., Hwang, W.Y., Yeh, J.J., Yoshigi, M., Ong, S.E., Schenone, M., Hartigan, C.R., Carr, S.A., Peterson, R.T. (2018) Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nature Chemical Biology. 14(9):844-852
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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