Gene
marcksb
- ID
- ZDB-GENE-030131-1921
- Name
- myristoylated alanine-rich protein kinase C substrate b
- Symbol
- marcksb Nomenclature History
- Previous Names
-
- macs (1)
- marcks
- wu:fb55c06
- wu:fb92d04
- wu:fc19b04
- wu:fc44a10
- zgc:110235
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Involved in positive regulation of BMP secretion. Acts upstream of or within several processes, including gastrulation; retina layer formation; and skeletal muscle cell differentiation. Predicted to be located in cytoskeleton and membrane. Predicted to be active in actin filament bundle; cytoplasm; and plasma membrane. Is expressed in several structures, including nervous system; neural plate; neural rod; neural tube; and neuroectoderm. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903275 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb199 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| ihb200 | Allele with one delins | Unknown | Frameshift | CRISPR | |
| sa6465 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36365 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa39154 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-marcksb | (2) | |
| MO1-marcksb | N/A | (3) |
| MO2-marcksb | N/A | Ott et al., 2011 |
| MO3-marcksb | N/A | Prieto et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR002101 | Myristoylated alanine-rich C-kinase substrate MARCKS |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Myristoylated alanine-rich C-kinase substrate MARCKS |
|---|---|---|---|
| UniProtKB:F6NXD5 | InterPro | 227 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
marcksb-201
(1)
|
Ensembl | 1,919 nt | ||
| mRNA |
marcksb-203
(1)
|
Ensembl | 3,771 nt | ||
| ncRNA |
marcksb-002
(1)
|
Ensembl | 317 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266G18 | ZFIN Curated Data | |
| Contains | SNP | rs3728848 | ZFIN Curated Data | |
| Encodes | EST | fb55c06 | ||
| Encodes | EST | fb92d04 | ||
| Encodes | EST | fc19b04 | ||
| Encodes | EST | fc44a10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:2601723 | ||
| Encodes | EST | IMAGE:6903275 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110235 | Strausberg et al., 2002 | |
| Encodes | cDNA | MGC:192319 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001015060 (1) | 2812 nt | ||
| Genomic | GenBank:CU306817 (1) | 176617 nt | ||
| Polypeptide | UniProtKB:F6NXD5 (1) | 227 aa |
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- Xie, Y., Xie, J., Meijer, A.H., Schaaf, M.J.M. (2021) Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages. Frontiers in immunology. 12:618569
- Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., Sun, Y. (2019) Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLoS Genetics. 15:e1008306
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Prieto, D., Zolessi, F.R. (2017) Functional Diversification of the Four MARCKS Family Members in Zebrafish Neural Development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(1-2):119-138
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Luo, Q., Wu, C., Sun, S., Lu, F., Xie, L., Zhao, H., Zhong, X., Zhou, Q. (2016) The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Journal of Fish Biology. 88(4):1584-97
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Wang, Y.W., Wei, C.Y., Dai, H.P., Zhu, Z.Y., and Sun, Y.H. (2013) Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Gene. 521(1):69-77
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