Gene
pik3cb
- ID
- ZDB-GENE-030131-1904
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
- Symbol
- pik3cb Nomenclature History
- Previous Names
-
- fb92a07
- wu:fb92a07
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; intracellular signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process and phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
| Domain | IPR003113 | Phosphatidylinositol 3-kinase, adaptor-binding domain |
| Family | IPR015433 | Phosphatidylinositol kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
| Homologous_superfamily | IPR042236 | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F251 | InterPro | 1080 | |||||||||||||
| UniProtKB:A0AB32T5E4 | InterPro | 1057 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3cb-201
(1)
|
Ensembl | 4,934 nt | ||
| mRNA |
pik3cb-202
(1)
|
Ensembl | 5,316 nt |
Interactions and Pathways
No data available
Plasmids
No data available