Gene
pik3cb
- ID
- ZDB-GENE-030131-1904
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
- Symbol
- pik3cb Nomenclature History
- Previous Names
-
- fb92a07
- wu:fb92a07
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; intracellular signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process and phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16161 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16592 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42487 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42488 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45529 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F251 | InterPro | 1080 | |||||||||||||
| UniProtKB:A0AB32T5E4 | InterPro | 1057 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3cb-201
(1)
|
Ensembl | 4,934 nt | ||
| mRNA |
pik3cb-202
(1)
|
Ensembl | 5,316 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-189G16 | ZFIN Curated Data | |
| Contained in | BAC | CH73-232G7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-61A15 | ZFIN Curated Data | |
| Contains | SNP | rs3728696 | ZFIN Curated Data | |
| Encodes | EST | fb92a07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068213678 (1) | 4053 nt | ||
| Genomic | GenBank:CR513781 (2) | 158040 nt | ||
| Polypeptide | UniProtKB:E7F251 (1) | 1080 aa |