ZFIN is now using GRCz12tu for Genomic Data
Gene
smurf2
- ID
- ZDB-GENE-030131-1830
- Name
- SMAD specific E3 ubiquitin protein ligase 2
- Symbol
- smurf2 Nomenclature History
- Previous Names
-
- wu:fb82a11
- wu:fc41c02
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable SMAD binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein catabolic process and regulation of signal transduction. Predicted to be located in several cellular components, including cytosol; lysosome; and membrane raft. Predicted to be active in cytoplasm. Is expressed in female organism and male organism. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Arslan-Ergul et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Family | IPR024928 | E3 ubiquitin-protein ligase, SMURF1 type |
| Family | IPR050409 | E3 ubiquitin-protein ligase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | E3 ubiquitin-protein ligase | E3 ubiquitin-protein ligase, SMURF1 type | HECT domain | HECT, E3 ligase catalytic domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIZ2 | InterPro | 764 | ||||||||
| UniProtKB:A9JRZ0 | InterPro | 765 | ||||||||
| UniProtKB:A0AB32TDF5 | InterPro | 775 | ||||||||
| UniProtKB:A0AB32TJA5 | InterPro | 774 | ||||||||
| UniProtKB:A0AC58IW97 | InterPro | 553 | ||||||||
| UniProtKB:A0AC58IWA2 | InterPro | 764 | ||||||||
| UniProtKB:A0AC58IWC1 | InterPro | 552 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smurf2-201
(1)
|
Ensembl | 3,399 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers