Gene

smurf2

ID

ZDB-GENE-030131-1830

Name

SMAD specific E3 ubiquitin protein ligase 2

Symbol

smurf2 Nomenclature History

Previous Names

wu:fb82a11
wu:fc41c02

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of BMP signaling pathway; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to localize to cytoplasm. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Arslan-Ergul et al., 2014

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smurf2 Human Ortholog

No data available

Associated With smurf2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Family	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
Family	IPR050409	E3 ubiquitin-protein ligase
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily