Gene

nfkbiab

ID

ZDB-GENE-030131-1819

Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b

Symbol

nfkbiab Nomenclature History

Previous Names

Ikbab
nfkbia
wu:fb81f08
zgc:56666 (1)
zgc:77616 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable NF-kappaB binding activity and protein sequestering activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to be active in cytosol. Is expressed in EVL; epidermis; lateral line system; vent; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56666 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfkbiab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ectodermal dysplasia and immunodeficiency 2	Alliance	Ectodermal dysplasia and immunodeficiency 2	612132

Associated With nfkbiab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR051070	NF-kappa-B Inhibitor
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Additional Resources	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	NF-kappa-B Inhibitor
UniProtKB:Q7ZW68	InterPro	312

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nfkbiab-201 (1) Ensembl	Ensembl	1,354 nt	Select Tool ZFIN BLAST
mRNA	nfkbiab-204 (1) Ensembl	Ensembl	5,069 nt	Select Tool ZFIN BLAST
ncRNA	nfkbiab-002 (1) Ensembl	Ensembl	768 nt	Select Tool ZFIN BLAST
ncRNA	nfkbiab-003 (1) Ensembl	Ensembl	832 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations