Gene
nfkbiab
- ID
- ZDB-GENE-030131-1819
- Name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
- Symbol
- nfkbiab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable NF-kappaB binding activity and protein sequestering activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to be active in cytosol. Is expressed in EVL; epidermis; lateral line system; vent; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56666 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18322 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia and immunodeficiency 2 | Alliance | Ectodermal dysplasia and immunodeficiency 2 | 612132 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | NF-kappa-B Inhibitor |
|---|---|---|---|---|---|
| UniProtKB:Q7ZW68 | InterPro | 312 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfkbiab-201
(1)
|
Ensembl | 1,354 nt | ||
| mRNA |
nfkbiab-204
(1)
|
Ensembl | 5,069 nt | ||
| ncRNA |
nfkbiab-002
(1)
|
Ensembl | 768 nt | ||
| ncRNA |
nfkbiab-003
(1)
|
Ensembl | 832 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-33B5 | ZFIN Curated Data | |
| Encodes | EST | fb81f08 | ||
| Encodes | cDNA | MGC:56666 | ||
| Encodes | cDNA | MGC:77616 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199629 (1) | 1337 nt | ||
| Genomic | GenBank:BX649530 (2) | 150656 nt | ||
| Polypeptide | UniProtKB:Q7ZW68 (1) | 312 aa |
- Deng, D., Zhao, B., Yang, H., Wang, S., Geng, Z., Zhou, J., Yang, G., Han, L. (2025) Investigating the Effect and Potential Mechanism of Rhamnetin 3-O-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro. Pharmaceuticals (Basel, Switzerland). 18:
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Zhao, Y., Lv, H., Yu, C., Liang, J., Yu, H., Du, Z., Zhang, R. (2024) Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration. Biochimica et biophysica acta. Molecular basis of disease. 1870(7):167442
- Rosa, I.F., Peçanha, A.P.B., Carvalho, T.R.B., Alexandre, L.S., Ferreira, V.G., Doretto, L.B., Souza, B.M., Nakajima, R.T., da Silva, P., Barbosa, A.P., Gomes-de-Pontes, L., Bomfim, C.G., Machado-Santelli, G.M., Condino-Neto, A., Guzzo, C.R., Peron, J.P.S., Andrade-Silva, M., Câmara, N.O.S., Garnique, A.M.B., Medeiros, R.J., Ferraris, F.K., Barcellos, L.J.G., Correia-Junior, J.D., Galindo-Villegas, J., Machado, M.F.R., Castoldi, A., Oliveira, S.L., Costa, C.C., Belo, M.A.A., Galdino, G., Sgro, G.G., Bueno, N.F., Eto, S.F., Veras, F.P., Fernandes, B.H.V., Sanches, P.R.S., Cilli, E.M., Malafaia, G., Nóbrega, R.H., Garcez, A.S., Carrilho, E., Charlie-Silva, I. (2023) Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model. International Journal of Molecular Sciences. 24(7):
- Wu, C., Zhang, W., Luo, Y., Cheng, C., Wang, X., Jiang, Y., Li, S., Luo, L., Yang, Y. (2023) Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis. Journal of genetics and genomics = Yi chuan xue bao. 50(12):1004-1013
- Yehuda, H., Madrer, N., Goldberg, D., Soreq, H., Meerson, A. (2023) Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Cells. 12(13):
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Chatterjee, A., Maity, S., Banerjee, S., Dutta, S., Adhikari, M., Guchhait, R., Biswas, C., De, S., Pramanick, K. (2022) Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis. The Science of the total environment. 830:154796
- Wasana, W.P., Senevirathne, A., Nikapitiya, C., Eom, T.Y., Lee, Y., Lee, J.S., Kang, D.H., Oh, C., De Zoysa, M. (2021) A Novel Pseudoalteromonas xiamenensis Marine Isolate as a Potential Probiotic: Anti-Inflammatory and Innate Immune Modulatory Effects against Thermal and Pathogenic Stresses. Marine drugs. 19(12):
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