Gene
lgi1a
- ID
- ZDB-GENE-030131-1731
- Name
- leucine-rich, glioma inactivated 1a
- Symbol
- lgi1a Nomenclature History
- Previous Names
-
- fb78h12
- wu:fb78h12
- zgc:65886
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have catalytic activity. Involved in brain development; locomotory behavior; and myelination. Human ortholog(s) of this gene implicated in childhood absence epilepsy and familial temporal lobe epilepsy 1. Is expressed in digestive system; heart; immature eye; nervous system; and skeletal muscle. Orthologous to several human genes including LGI1 (leucine rich glioma inactivated 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial temporal lobe epilepsy 1 | Alliance | Epilepsy, familial temporal lobe, 1 | 600512 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Family | IPR051295 | Leucine-rich glioma-inactivated/LGI-related |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR005492 | Leucine-rich glioma-inactivated , EPTP repeat |
| Repeat | IPR009039 | EAR |
Domain Details Per Protein
| Protein | Length | Cysteine-rich flanking region, C-terminal | EAR | Leucine-rich glioma-inactivated , EPTP repeat | Leucine-rich glioma-inactivated/LGI-related | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q2HPG2
|
537 | |||||||
|
UniProtKB:F6NUE1
|
536 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available