Gene
mid1ip1l
- ID
- ZDB-GENE-030131-1697
- Name
- MID1 interacting protein 1, like
- Symbol
- mid1ip1l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Acts upstream of or within regulation of cytoskeleton organization and regulation of ribonucleoprotein complex localization. Predicted to be located in cytoplasm; microtubule; and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including blastomere; hindbrain neural plate; nervous system; polster; and yolk syncytial layer. Orthologous to human THRSP (thyroid hormone responsive).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb505 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-mid1ip1l | (3) | |
CRISPR2-mid1ip1l | Moravec et al., 2021 | |
CRISPR3-mid1ip1l | Moravec et al., 2021 | |
CRISPR4-mid1ip1l | Moravec et al., 2021 | |
CRISPR5-mid1ip1l | Moravec et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Lipogenesis and Microtubule Stabilization Superfamily | Spot 14 family |
---|---|---|---|---|
UniProtKB:B2GNN4 | InterPro | 165 | ||
UniProtKB:Q8AWD1 | InterPro | 165 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mid1ip1l-201
(1)
|
Ensembl | 1,278 nt | ||
mRNA |
mid1ip1l-202
(1)
|
Ensembl | 683 nt | ||
mRNA |
mid1ip1l-203
(1)
|
Ensembl | 499 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-221C23 | ZFIN Curated Data | |
Encodes | EST | cb505 | Thisse et al., 2001 | |
Encodes | EST | fb78b10 | ||
Encodes | EST | fj81h03 | ||
Encodes | EST | fq35d03 | Rauch et al., 2003 | |
Encodes | cDNA | MGC:55658 | ZFIN Curated Data | |
Encodes | cDNA | MGC:55736 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77189 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191200 | ZFIN Curated Data | |
Has Artifact | cDNA | MGC:112497 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213439 (1) | 1256 nt | ||
Genomic | GenBank:CU459160 (1) | 150342 nt | ||
Polypeptide | UniProtKB:B2GNN4 (1) | 165 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Woods, et al. 2005. (ZDB-PUB-050823-6) reported orthology to human MID1IP1 based on amino acid similarity. Subsequent data suggests mid1ip1a (ZDB-GENE-990415-81) and mid1ip1b (ZDB-GENE-040426-1720) are orthologs of human MID1IP1.
No data available
- Nair, S., Welch, E.L., Moravec, C.E., Trevena, R.L., Hansen, C.L., Pelegri, F. (2023) The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Development (Cambridge, England). 150(4)
- Sugasawa, T., Komine, R., Manevich, L., Tamai, S., Takekoshi, K., Kanki, Y. (2022) Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle. Nutrients. 14(11)
- Moravec, C.E., Voit, G.C., Otterlee, J., Pelegri, F. (2021) Identification of maternal-effect genes in zebrafish using maternal crispants. Development (Cambridge, England). 148(19)
- Eno, C., Hansen, C.L., Pelegri, F. (2019) Aggregation, segregation and dispersal of homotypic germ plasm RNPs in the early zebrafish embryo. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(4):306-318
- Eno, C., Pelegri, F. (2018) Modulation of F-actin dynamics by maternal mid1ip1L controls germ plasm aggregation and furrow recruitment in the zebrafish embryo. Development (Cambridge, England). 145(10)
- Eno, C., Solanki, B., Pelegri, F. (2016) aura/mid1ip1L regulates the cytoskeleton at the zebrafish egg-to-embryo transition. Development (Cambridge, England). 143(9):1585-99
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
- Desai, S., Heffelfinger, A.K., Orcutt, T.M., Litman, G.W., and Yoder, J.A. (2008) The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains. BMC Evolutionary Biology. 8:177
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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