ZFIN is now using GRCz12tu for Genomic Data
Gene
ewsr1b
- ID
- ZDB-GENE-030131-1600
- Name
- EWS RNA-binding protein 1b
- Symbol
- ewsr1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz11
- Annotation Status
- Unknown
- Description
- Predicted to enable RNA binding activity and transcription coregulator activity. Acts upstream of or within central nervous system neuron development and mitotic cell cycle. Predicted to be active in nucleus. Is expressed in fin bud; gut; nervous system; and trunk. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Azuma et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ewing sarcoma | Alliance | Ewing sarcoma | 612219 |
| Ewing sarcoma | Alliance | Neuroepithelioma | 612219 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Family | IPR034870 | TAF15/EWS/TLS family |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAF15/EWS/TLS family | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q803E3 | InterPro | 578 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ewsr1b-201
(1)
|
Ensembl | 2,083 nt | ||
| mRNA |
ewsr1b-202
(1)
|
Ensembl | 2,441 nt | ||
| mRNA |
ewsr1b-204
(1)
|
Ensembl | 897 nt | ||
| ncRNA |
ewsr1b-003
(1)
|
Ensembl | 1,207 nt | ||
| ncRNA |
ewsr1b-005
(1)
|
Ensembl | 780 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers