Gene
id2b
- ID
- ZDB-GENE-030131-15
- Name
- inhibitor of DNA binding 2b
- Symbol
- id2b Nomenclature History
- Previous Names
-
- id2l
- hm:zeh0152
- zgc:73382
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and neuron differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; liver; nervous system; notochord; and pronephric duct. Orthologous to human ID2 (inhibitor of DNA binding 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73382 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021527Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23730 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-id2b | (2) | |
| CRISPR2-id2b | Sahu et al., 2021 | |
| CRISPR3-id2b | Sahu et al., 2021 | |
| MO1-id2b | N/A | Uribe et al., 2010 |
| MO2-id2b | N/A | Sahu et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA-binding protein inhibitor | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:Q6PBJ0
|
130 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(id2b:GAL4-VP16,myl7:VP16) |
|
| 1 | (7) | |
| Tg(hsp70l:id2b-2A-GFP) |
| 1 | Sahu et al., 2021 | ||
| Tg(myl7:id2b-2A-Tomato) |
| 1 | Fukuda et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-7F8 | ZFIN Curated Data | |
| Encodes | EST | zeh0152 | ||
| Encodes | cDNA | MGC:73382 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113955 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192583 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199541 (1) | 1463 nt | ||
| Genomic | GenBank:BX293564 (1) | 145495 nt | ||
| Polypeptide | UniProtKB:Q6PBJ0 (1) | 130 aa |
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Sahu, A., Devi, S., Jui, J., Goldman, D. (2021) Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia. 69(12):2882-2898
- Wang, W., Hu, Y.F., Pang, M., Chang, N., Yu, C., Li, Q., Xiong, J.W., Peng, Y., Zhang, R. (2021) BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration. International journal of biological sciences. 17:2157-2166
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Xiao, Y., Chen, J., Wan, Y., Gao, Q., Jing, N., Zheng, Y., Zhu, X. (2019) Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Cell discovery. 5:37
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Förster, D., Arnold-Ammer, I., Laurell, E., Barker, A.J., Fernandes, A.M., Finger-Baier, K., Filosa, A., Helmbrecht, T.O., Kölsch, Y., Kühn, E., Robles, E., Slanchev, K., Thiele, T.R., Baier, H., Kubo, F. (2017) Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools. Scientific Reports. 7:5230
- Fukuda, R., Gunawan, F., Beisaw, A., Jimenez-Amilburu, V., Maischein, H.M., Kostin, S., Kawakami, K., Stainier, D.Y. (2017) Proteolysis regulates cardiomyocyte maturation and tissue integration. Nature communications. 8:14495
- Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
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