ZFIN is now using GRCz12tu for Genomic Data
Gene
zrsr2
- ID
- ZDB-GENE-030131-1495
- Name
- zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
- Symbol
- zrsr2 Nomenclature History
- Previous Names
-
- fb73a09
- wu:fb73a09
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable pre-mRNA 3'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2AF complex and spliceosomal complex. Is expressed in blood island; brain; intestinal bulb; and telencephalon. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Weinstein et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Orofaciodigital syndrome XXI | 301132 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR000571 | Zinc finger, CCCH-type |
| Domain | IPR003954 | RNA recognition motif domain, eukaryotic-type |
| Family | IPR009145 | U2 auxiliary factor small subunit |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | RNA recognition motif domain, eukaryotic-type | U2 auxiliary factor small subunit | Zinc finger, CCCH-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B2P4 | InterPro | 483 | ||||||
| UniProtKB:A0A8M1QHE8 | InterPro | 635 | ||||||
| UniProtKB:A0A8M9Q815 | InterPro | 635 | ||||||
| UniProtKB:A0AC58GS86 | InterPro | 483 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zrsr2-201
(1)
|
Ensembl | 3,061 nt | ||
| mRNA |
zrsr2-204
(1)
|
Ensembl | 2,318 nt | ||
| ncRNA |
ottdart00000061864
(1)
|
Ensembl | 885 nt | ||
| ncRNA |
ottdart00000061865
(1)
|
Ensembl | 717 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers