Gene

zrsr2

ID

ZDB-GENE-030131-1495

Name

zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2

Symbol

zrsr2 Nomenclature History

Previous Names

fb73a09
wu:fb73a09

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable pre-mRNA 3'-splice site binding activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of cartilage development. Predicted to be part of U2AF complex and spliceosomal complex. Is expressed in blood island; brain; intestinal bulb; and telencephalon. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Weinstein et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zrsr2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Orofaciodigital syndrome XXI	301132

Associated With zrsr2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR000571	Zinc finger, CCCH-type
Family	IPR009145	U2 auxiliary factor small subunit
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain	U2 auxiliary factor small subunit	Zinc finger, CCCH-type
UniProtKB:A0A8M2B2P4 InterPro	483
UniProtKB:A0A8M1QHE8 InterPro	635

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zrsr2-201 (1) Ensembl	Ensembl	3,061 nt	Select Tool ZFIN BLAST
mRNA	zrsr2-204 (1) Ensembl	Ensembl	2,318 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000061864 (1) Ensembl	Ensembl	885 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000061865 (1) Ensembl	Ensembl	717 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations