Gene

zrsr2

ID
ZDB-GENE-030131-1495
Name
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
Symbol
zrsr2 Nomenclature History
Previous Names
  • fb73a09
  • wu:fb73a09
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable pre-mRNA 3'-splice site binding activity. Acts upstream of or within hematopoietic stem cell homeostasis and regulation of cartilage development. Predicted to be part of U2AF complex and spliceosomal complex. Is expressed in blood island; brain; intestinal bulb; and telencephalon. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Weinstein et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hg129Allele with one deletionExon 7FrameshiftCRISPR
Zebrafish International Resource Center (ZIRC) (order this)
sa38832Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
sa41794Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-zrsr2 (2)
CRISPR2-zrsr2 (2)
CRISPR3-zrsr2
    		Avagyan et al., 2021
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    Human Disease
    Associated With zrsr2 Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Orofaciodigital syndrome XXI 301132
    1 - 1 of 1
    Associated With zrsr2 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Domain IPR000504 RNA recognition motif domain
    Domain IPR000571 Zinc finger, CCCH-type
    Domain IPR003954 RNA recognition motif domain, eukaryotes
    Family IPR009145 U2 auxiliary factor small subunit
    Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    1 - 5 of 6 Show all
    Domain Details Per Protein
    Protein Additional Resources Length Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA recognition motif domain RNA recognition motif domain, eukaryotes U2 auxiliary factor small subunit Zinc finger, CCCH-type
    UniProtKB:A0A8M2B2P4 InterPro 483
    UniProtKB:A0A8M1QHE8 InterPro 635
    1 - 2 of 2
    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 11
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA zrsr2-201 (1)
    Ensembl
    		Ensembl 3,061 nt
    ZFIN BLAST
    mRNA zrsr2-204 (1)
    Ensembl
    		Ensembl 2,318 nt
    ZFIN BLAST
    ncRNA ottdart00000061864 (1)
    Ensembl
    		Ensembl 885 nt
    ZFIN BLAST
    ncRNA ottdart00000061865 (1)
    Ensembl
    		Ensembl 717 nt
    ZFIN BLAST
    1 - 4 of 4
    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACCH211-209F22ZFIN Curated Data
    Contained inBACDKEY-225B20
    EncodesESTfb73a09
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    Sequences
    Type Accession # Sequence Length (nt/aa) Analysis
    RNARefSeq:XM_001920527 (1)3053 nt
    ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
    GenomicGenBank:CR450764 (1)152815 nt
    MegaBLASTEnsembl
    PolypeptideUniProtKB:A0A8M1QHE8 (1)635 aa
    ZFIN BLASTSIB BLASTEnsembl Protein Blast
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanZRSR2X
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (1)
    Citations
    TSV
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