Gene

plg

ID
ZDB-GENE-030131-1411
Name
plasminogen
Symbol
plg Nomenclature History
Previous Names
  • wu:fb70e09
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable endopeptidase activity and signaling receptor binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Predicted to be extrinsic component of plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; conjunctivitis; hereditary angioedema; myocardial infarction; and plasminogen deficiency type I. Orthologous to several human genes including PLG (plasminogen).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
plasminogen deficiency type I Alliance Dysplasminogenemia 217090
plasminogen deficiency type I Alliance Plasminogen deficiency, type I 217090
Angioedema, hereditary, 4 619360
Associated With plg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR003609 PAN/Apple domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR023317 Peptidase S1A, plasmin
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR038178 Kringle superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Kringle Kringle, conserved site Kringle-like fold Kringle superfamily PAN/Apple domain Peptidase S1A, chymotrypsin family Peptidase S1A, plasmin Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site
UniProtKB:F1Q890 818
UniProtKB:Q6PBA6 818
UniProtKB:Q8AVB0 429
UniProtKB:E9QGF2 148
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations