Gene
plg
- ID
- ZDB-GENE-030131-1411
- Name
- plasminogen
- Symbol
- plg Nomenclature History
- Previous Names
-
- wu:fb70e09
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable endopeptidase activity and signaling receptor binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within hemostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Predicted to be extrinsic component of plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; conjunctivitis; hereditary angioedema; myocardial infarction; and plasminogen deficiency type I. Orthologous to several human genes including PLG (plasminogen).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| plasminogen deficiency type I | Alliance | Dysplasminogenemia | 217090 |
| plasminogen deficiency type I | Alliance | Plasminogen deficiency, type I | 217090 |
| Angioedema, hereditary, 4 | 619360 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR003609 | PAN/Apple domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR023317 | Peptidase S1A, plasmin |
| Family | IPR050759 | Serine proteases and regulators with kringle domains |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Length | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | PAN/Apple domain | Peptidase S1A, chymotrypsin family | Peptidase S1A, plasmin | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases and regulators with kringle domains | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q890
|
818 |
Interactions and Pathways
No data available
Plasmids
No data available