Gene
plg
- ID
- ZDB-GENE-030131-1411
- Name
- plasminogen
- Symbol
- plg Nomenclature History
- Previous Names
-
- wu:fb70e09
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase activity. Predicted to be involved in several processes, including blood coagulation; fibrinolysis; and tissue remodeling. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in conjunctivitis; myocardial infarction; plasminogen deficiency type I; and thrombophilia. Is expressed in liver. Orthologous to several human genes including PLG (plasminogen).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| plasminogen deficiency type I | Alliance | Dysplasminogenemia | 217090 |
| plasminogen deficiency type I | Alliance | Plasminogen deficiency, type I | 217090 |
| Angioedema, hereditary, 4 | 619360 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Domain | IPR003609 | PAN/Apple domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR023317 | Peptidase S1A, plasmin |
| Family | IPR050759 | Serine proteases and regulators with kringle domains |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Length | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | PAN/Apple domain | Peptidase S1A, chymotrypsin family | Peptidase S1A, plasmin | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases and regulators with kringle domains | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q890
|
818 |
Interactions and Pathways
No data available
Plasmids
No data available