Gene
rab5aa
- ID
- ZDB-GENE-030131-139
- Name
- RAB5A, member RAS oncogene family, a
- Symbol
- rab5aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Predicted to be involved in endocytosis; intracellular protein transport; and regulation of long-term neuronal synaptic plasticity. Predicted to be located in early endosome membrane. Predicted to be active in axon; cytoplasmic vesicle; and plasma membrane. Is expressed in brain and trunk. Orthologous to human RAB5A (RAB5A, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56009 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17878 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTP-binding domain |
|---|---|---|---|---|---|
| UniProtKB:Q7ZUW5 | InterPro | 216 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rab5aa-201
(1)
|
Ensembl | 2,592 nt | ||
| mRNA |
rab5aa-202
(1)
|
Ensembl | 683 nt | ||
| ncRNA |
rab5aa-002
(1)
|
Ensembl | 691 nt |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(6xUAS:mNeonGreen-rab5aa) |
|
| 1 | Möller et al., 2022 | |
| Tg(slc20a1a:GFP-rab5aa,myl7:EGFP) |
| 1 | Chen et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-1J13 | ZFIN Curated Data | |
| Encodes | EST | fj38g08 | ||
| Encodes | EST | zehn1144 | ||
| Encodes | cDNA | MGC:56009 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77676 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193003 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201485 (1) | 2408 nt | ||
| Genomic | GenBank:BX950869 (2) | 91362 nt | ||
| Polypeptide | UniProtKB:Q7ZUW5 (1) | 216 aa |
- Möller, K., Brambach, M., Villani, A., Gallo, E., Gilmour, D., Peri, F. (2022) A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo. eLIFE. 11:
- Hartmann, J., Wong, M., Gallo, E., Gilmour, D. (2020) An image-based data-driven analysis of cellular architecture in a developing tissue. eLIFE. 9:
- Heng, J., Lv, P., Zhang, Y., Cheng, X., Wang, L., Ma, D., Liu, F. (2020) Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling. PLoS Biology. 18:e3000696
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Chen, Z., Luciani, A., Mateos, J.M., Barmettler, G., Giles, R.H., Neuhauss, S.C.F., Devuyst, O. (2019) Transgenic zebrafish modeling low-molecular-weight proteinuria and lysosomal storage diseases. Kidney International. 97(6):1150-1163
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
- Zhu, Y., Crowley, S.C., Latimer, A.J., Lewis, G.M., Nash, R., Kucenas, S. (2019) Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Cell. 179(1):74-89.e10
- Mochizuki, T., Kojima, Y., Nishiwaki, Y., Harakuni, T., Masai, I. (2018) Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish. Development (Cambridge, England). 145(20):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hall, T.E., Martel, N., Lo, H.P., Xiong, Z., Parton, R.G. (2017) A plasmid library of full-length zebrafish rab proteins for in vivo cell biology.. Cellular logistics. 7:e1301151
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