Gene
arg2
- ID
- ZDB-GENE-030131-1334
- Name
- arginase 2
- Symbol
- arg2 Nomenclature History
- Previous Names
-
- wu:fb67g02
- zgc:85630
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable arginase activity and manganese ion binding activity. Predicted to be involved in urea cycle. Predicted to act upstream of or within arginine metabolic process. Predicted to be active in mitochondrion. Is expressed in axial mesoderm; central nervous system; forerunner cell group; and integument. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85630 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Arginase | Ureohydrolase | Ureohydrolase domain superfamily | Ureohydrolase, manganese-binding site |
|---|---|---|---|---|---|---|
| UniProtKB:Q6PH54 | InterPro | 347 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(arg2:EGFP) |
|
| 2 | Hammond et al., 2023 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-12D10 | ZFIN Curated Data | |
| Encodes | EST | fb67g02 | ||
| Encodes | cDNA | MGC:65793 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85630 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199611 (1) | 2161 nt | ||
| Genomic | GenBank:BX470227 (2) | 177716 nt | ||
| Polypeptide | UniProtKB:Q6PH54 (1) | 347 aa |
- Gu, Z., Yin, J., Da Silva, C.G., Liu, Q., Cruz, L.J., Ossendorp, F., Snaar-Jagalska, E. (2024) Therapeutic liposomal combination to enhance chemotherapy response and immune activation of tumor microenvironment. Journal of controlled release : official journal of the Controlled Release Society. 373:38-54
- Yang, X.J., Huang, Z.H., Liu, W., Zhang, W.Q., Huang, Z.B. (2024) Identification and functional characterization of CD209 homologous genes in zebrafish. Yi chuan = Hereditas. 46:947957947-957
- Hammond, F.R., Lewis, A., Speirs, Z.C., Anderson, H.E., Sipka, T., Williams, L.G., Nguyen-Chi, M., Meijer, A.H., Wiegertjes, G.F., Elks, P.M. (2023) An arginase 2 promoter transgenic illuminates immune cell polarisation in zebrafish. Disease models & mechanisms. 16(6):
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Chen, A.Q., He, S.M., Lv, S.J., Qiu, C.Z., Zhou, R., Zhang, L., Zhang, S.R., Zhang, Z., Ren, D.L. (2022) Muscarinic acetylcholine receptors regulate inflammatory responses through arginases 1/2 in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 153:113321
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Rawson, A., Saxena, V., Gao, H., Hooks, J., Xuei, X., McGuire, P., Hato, T., Hains, D.S., Anderson, R.M., Schwaderer, A.L. (2022) A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Pathogens & immunity. 7:1-18
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Banerjee, B., Khrystoforova, I., Polis, B., Zvi, I.B., Karasik, D. (2021) Acute hypoxia elevates arginase 2 and induces polyamine stress response in zebrafish via evolutionarily conserved mechanism. Cellular and molecular life sciences : CMLS. 79(1):41
- Liao, Z., Lin, D., Jia, J., Cai, R., Yu, Y., Li, W. (2021) Innate Immune Response to Fasting and Refeeding in the Zebrafish Kidney. Biomolecules. 11(6):
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