Gene

uqcrc2b

ID

ZDB-GENE-030131-1269

Name

ubiquinol-cytochrome c reductase core protein 2b

Symbol

uqcrc2b Nomenclature History

Previous Names

uqcrc2
fi06a11 (1)
wu:fb64g04
wu:fi06a11 (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to contribute to endopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Predicted to localize to mitochondrial inner membrane and mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Is expressed in gut and liver. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139233 (1 image)
IMAGE:6905267 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With uqcrc2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial complex III deficiency nuclear type 5	Alliance	Mitochondrial complex III deficiency, nuclear type 5	615160

Associated With uqcrc2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR001431	Peptidase M16, zinc-binding site
Domain	IPR007863	Peptidase M16, C-terminal
Domain	IPR011765	Peptidase M16, N-terminal
Family	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex
Homologous_superfamily	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like