agt

ID

ZDB-GENE-030131-1205

Name

angiotensinogen

Symbol

agt Nomenclature History

Previous Names

wu:fb62f06
wu:fj87b02
zgc:111892

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in angiotensin-activated signaling pathway and regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; IgA vasculitis; artery disease (multiple); cerebrovascular disease (multiple); and heart conduction disease (multiple). Orthologous to human AGT (angiotensinogen).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With agt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Renal tubular dysgenesis	267430

Associated With agt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Domain	IPR033834	Angiotensinogen, serpin domain
Family	IPR000215	Serpin family
Family	IPR000227	Angiotensinogen
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2