Gene
apoc1
- ID
- ZDB-GENE-030131-1074
- Name
- apolipoprotein C-I
- Symbol
- apoc1 Nomenclature History
- Previous Names
-
- apoc1l
- fb58g10
- wu:fb58g10
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Acts upstream of or within cell migration involved in gastrulation. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Is expressed in DEL; blastoderm; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-apoc1 | (3) | |
| MO1-apoc1 | N/A | Wang et al., 2013 |
| MO2-apoc1 | N/A | Wang et al., 2013 |
| MO3-apoc1 | N/A | Wang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein C-I | Apolipoprotein C-I domain superfamily |
|---|---|---|---|---|
| UniProtKB:E9QFX0 | InterPro | 84 | ||
| UniProtKB:E9QDI1 | InterPro | 85 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7F3 | ZFIN Curated Data | |
| Contains | SNP | rs3728783 | ZFIN Curated Data | |
| Contains | SNP | rs3728784 | ZFIN Curated Data | |
| Encodes | EST | fb58g10 | ||
| Encodes | EST | IMAGE:7015412 | ||
| Has Artifact | cDNA | MGC:173647 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001291886 (1) | 799 nt | ||
| Genomic | GenBank:BX004983 (1) | 234489 nt | ||
| Polypeptide | UniProtKB:E9QDI1 (1) | 85 aa |
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Silva, N.J., Dorman, L.C., Vainchtein, I.D., Horneck, N.C., Molofsky, A.V. (2021) In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nature communications. 12:5916
- Thiel, W., Esposito, E.J., Findley, A.P., Blume, Z.I., Mitchell, D.M. (2021) Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Biology Open. 11(1):
- Chen, L., Lam, J.C., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B. (2020) Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental science & technology. 54(12):7494-7503
- Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Kuil, L.E., Oosterhof, N., Geurts, S.N., van der Linde, H.C., Meijering, E., van Ham, T.J. (2019) Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Disease models & mechanisms. 12(3):
- Mitchell, D.M., Sun, C., Hunter, S.S., New, D.D., Stenkamp, D.L. (2019) Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
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