Gene

agrn

ID
ZDB-GENE-030131-1033
Name
agrin
Symbol
agrn Nomenclature History
Previous Names
  • agrin
  • hm:gc12
  • sb:eu553
  • wu:fb57e07
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within anterior/posterior pattern specification and nervous system development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including immature eye; nervous system; neural tube; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With agrn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myasthenic syndrome 8 Alliance Myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects 615120
Associated With agrn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000082 SEA domain
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR002049 Laminin EGF domain
Domain IPR002350 Kazal domain
Domain IPR003645 Follistatin-like, N-terminal
Domain IPR003884 Factor I / membrane attack complex
Domain IPR004850 NtA (N-terminal agrin) domain
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR036058 Kazal domain superfamily
Homologous_superfamily IPR036364 SEA domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding domain EGF-like domain Factor I / membrane attack complex Follistatin-like, N-terminal Kazal domain Kazal domain superfamily Laminin EGF domain Laminin G domain NtA (N-terminal agrin) domain SEA domain SEA domain superfamily Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:B3GQ72 2028
UniProtKB:B3GQ71 1928
UniProtKB:A0A0R4IJ40 1926
UniProtKB:F1R074 2026
UniProtKB:A0A2R8RHN2 1943
UniProtKB:A0A0R4IPG9 1899
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations