Gene

agrn

ID
ZDB-GENE-030131-1033
Name
agrin
Symbol
agrn Nomenclature History
Previous Names
  • agrin
  • hm:gc12
  • sb:eu553
  • wu:fb57e07
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase inhibitor activity. Involved in anterior/posterior pattern specification and nervous system development. Predicted to localize to integral component of membrane. Is expressed in several structures, including immature eye; nervous system; neural tube; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With agrn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myasthenic syndrome 8 Alliance Myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects 615120
Associated With agrn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Domain IPR000082 SEA domain
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR002049 Laminin EGF domain
Domain IPR002350 Kazal domain
Domain IPR003645 Follistatin-like, N-terminal
Domain IPR003884 Factor I / membrane attack complex
Domain IPR004850 NtA (N-terminal agrin) domain
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR036058 Kazal domain superfamily
Homologous_superfamily IPR036364 SEA domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain Factor I / membrane attack complex Follistatin-like, N-terminal Kazal domain Kazal domain superfamily Laminin EGF domain Laminin G domain NtA (N-terminal agrin) domain SEA domain SEA domain superfamily Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:A0A2R8RHN2 1943
UniProtKB:F1R074 2026
UniProtKB:B3GQ72 2028
UniProtKB:B3GQ71 1928
UniProtKB:A0A0R4IJ40 1926
UniProtKB:A0A0R4IPG9 1899
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations