Gene

sirt2

ID
ZDB-GENE-030131-1028
Name
sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Symbol
sirt2 Nomenclature History
Previous Names
  • wu:fb57d05
  • zgc:77003
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have NAD+ binding activity; protein deacetylase activity; and transcription factor binding activity. Involved in cilium assembly and negative regulation of angiogenesis. Predicted to localize to several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la019489TgTransgenic insertionUnknownUnknownDNA
sa9082Allele with one point mutationUnknownPremature StopENU
sa13413Allele with one point mutationUnknownPremature StopENU
sh626Allele with one delinsExon 4UnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With sirt2 Human Ortholog
No data available
Associated With sirt2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR026590 Sirtuin family, catalytic core domain
Family IPR003000 Sirtuin family
Family IPR017328 Sirtuin, class I
Family IPR050134 NAD-dependent sirtuin protein deacylases
Homologous_superfamily IPR026591 Sirtuin, catalytic core small domain superfamily
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Domain Details Per Protein
Protein Length DHS-like NAD/FAD-binding domain superfamily NAD-dependent sirtuin protein deacylases Sirtuin, catalytic core small domain superfamily Sirtuin, class I Sirtuin family Sirtuin family, catalytic core domain
UniProtKB:A0A8M3ASG7 343
UniProtKB:Q7ZVK3 379
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sirt2-201 (1) Ensembl 2,589 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-228B5ZFIN Curated Data
EncodesESTfb57d05
EncodescDNAMGC:55966ZFIN Curated Data
EncodescDNAMGC:77003ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSIRT219
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseSirt27
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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