Gene
sirt2
- ID
- ZDB-GENE-030131-1028
- Name
- sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
- Symbol
- sirt2 Nomenclature History
- Previous Names
-
- wu:fb57d05
- zgc:77003
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have NAD+ binding activity; protein deacetylase activity; and transcription factor binding activity. Involved in cilium assembly and negative regulation of angiogenesis. Predicted to localize to several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55966 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la019489Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa9082 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa13413 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sh626 | Allele with one delins | Exon 4 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-sirt2 | Łysyganicz et al., 2021 | |
MO1-sirt2 | N/A | Huang et al., 2013 |
MO2-sirt2 | N/A | (3) |
MO3-sirt2 | N/A | Zhou et al., 2014 |
MO4-sirt2 | N/A | Fiskus et al., 2016 |
MO5-sirt2 | N/A | Shi et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR026590 | Sirtuin family, catalytic core domain |
Family | IPR003000 | Sirtuin family |
Family | IPR017328 | Sirtuin, class I |
Family | IPR050134 | NAD-dependent sirtuin protein deacylases |
Homologous_superfamily | IPR026591 | Sirtuin, catalytic core small domain superfamily |
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Domain Details Per Protein
Protein | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin, catalytic core small domain superfamily | Sirtuin, class I | Sirtuin family | Sirtuin family, catalytic core domain |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3ASG7
|
343 | ||||||
UniProtKB:Q7ZVK3
|
379 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-228B5 | ZFIN Curated Data | |
Encodes | EST | fb57d05 | ||
Encodes | cDNA | MGC:55966 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77003 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199596 (1) | 2545 nt | ||
Genomic | GenBank:CU693501 (2) | 37734 nt | ||
Polypeptide | UniProtKB:Q7ZVK3 (1) | 379 aa |
- Hayasaka, O., Shibukawa, M., Kamei, H. (2024) Cellular Energy Sensor Sirt1 Augments Mapk Signaling to Promote Hypoxia/Reoxygenation-Induced Catch-up Growth in Zebrafish Embryo. Zoological science. 41:213121-31
- Tian, Y., Lautrup, S., Law, P.W.N., Dinh, N.D., Fang, E.F., Chan, W.Y. (2024) WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Cell & Bioscience. 14:77
- Ding, Q., Zhang, Z., Li, Y., Liu, H., Hao, Q., Yang, Y., Ringø, E., Olsen, R.E., Clarke, J.L., Ran, C., Zhou, Z. (2021) Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. iScience. 24:102515
- Łysyganicz, P.K., Pooranachandran, N., Liu, X., Adamson, K.I., Zielonka, K., Elworthy, S., van Eeden, F.J., Grierson, A.J., Malicki, J.J. (2021) Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Frontiers in cell and developmental biology. 9:676214
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Morishima, T., Krahl, A.C., Nasri, M., Xu, Y., Aghaallaei, N., Findik, B., Klimiankou, M., Ritter, M., Hartmann, M.D., Gloeckner, C.J., Stefańczyk, S., Lindner, C., Oswald, B., Bernhard, R., Hähnel, K., Hermanutz-Klein, U., Ebinger, M., Handgretinger, R., Casadei, N., Welte, K., Andre, M., Müller, P., Bajoghli, B., Skokowa, J. (2019) LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. Blood. 134(14):1159-1175
- Sheng, W., Lu, Y., Mei, F., Wang, N., Liu, Z.Z., Han, Y.Y., Wang, H.T., Zou, S., Xu, H., Zhang, X. (2018) Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Investigative ophthalmology & visual science. 59:4542-4551
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Fiskus, W., Coothankandaswamy, V., Chen, J., Ma, H., Ha, K., Saenz, D.T., Krieger, S.S., Mill, C.P., Sun, B., Huang, P., Mumm, J.S., Melnick, A., Bhalla, K.N. (2016) SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress inducing agents. Cancer research. 76(18):5467-78
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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