Gene
prkar2aa
- ID
- ZDB-GENE-030131-1007
- Name
- protein kinase, cAMP-dependent, regulatory, type II, alpha A
- Symbol
- prkar2aa Nomenclature History
- Previous Names
-
- wu:fb55f12
- wu:fj29e12
- wu:fj33e06
- zgc:153742
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within phosphorylation and regulation of protein phosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la026463Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa15178 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa34419 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 3 of 3
Show
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
Domain | IPR000595 | Cyclic nucleotide-binding domain |
Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
Family | IPR050503 | cAMP-dependent protein kinase regulatory subunit-like |
1 - 5 of 7 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP-dependent protein kinase regulatory subunit-like | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RmlC-like jelly roll fold |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A9C3T0 | InterPro | 397 | |||||||
UniProtKB:Q08BH1 | InterPro | 397 |
1 - 2 of 2
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
antisense |
ottdart00000059334
(1)
|
Ensembl | 451 nt | ||
mRNA |
prkar2aa-201
(1)
|
Ensembl | 3,514 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-20D21 | ZFIN Curated Data | |
Encodes | EST | fb55f12 | ||
Encodes | EST | fj29e12 | ||
Encodes | EST | fj33e06 | ||
Encodes | cDNA | MGC:153742 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191668 | ZFIN Curated Data |
1 - 6 of 6
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077370 (1) | 2720 nt | ||
Genomic | GenBank:CR847503 (1) | 217514 nt | ||
Polypeptide | UniProtKB:A9C3T0 (1) | 397 aa |
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Hölper, S., Housley, M.P., Islam, S., Piller, T., Konzer, A., Stainier, D.Y., Braun, T., Krüger, M. (2015) Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Proteomics. 15(4):739-51
- Maeda, R., Kindt, K.S., Mo, W., Morgan, C.P., Erickson, T., Zhao, H., Clemens-Grisham, R., Barr-Gillespie, P.G., Nicolson, T. (2014) Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proceedings of the National Academy of Sciences of the United States of America. 111(35):12907-12
- Singh, S.K., Aravamudhan, S., Armant, O., Krüger, M., Grabher, C. (2014) Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Fish & shellfish immunology. 40(1):217-24
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Goehring, A.S., Pedroja, B.S., Hinke, S.A., Langeberg, L.K., and Scott, J.D. (2007) MyRIP anchors protein kinase A to the exocyst complex. The Journal of biological chemistry. 282(45):33155-33167
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 10 of 12
Show