Gene
prkar2aa
- ID
- ZDB-GENE-030131-1007
- Name
- protein kinase, cAMP-dependent, regulatory, type II, alpha A
- Symbol
- prkar2aa Nomenclature History
- Previous Names
-
- wu:fb55f12
- wu:fj29e12
- wu:fj33e06
- zgc:153742
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within phosphorylation and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Family | IPR050503 | cAMP-dependent protein kinase regulatory subunit-like |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP-dependent protein kinase regulatory subunit-like | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9C3T0 | InterPro | 397 | |||||||
| UniProtKB:Q08BH1 | InterPro | 397 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000059334
(1)
|
Ensembl | 451 nt | ||
| mRNA |
prkar2aa-201
(1)
|
Ensembl | 3,514 nt |
Interactions and Pathways
No data available
Plasmids
No data available