Gene

smad7

ID

ZDB-GENE-030128-3

Name

SMAD family member 7

Symbol

smad7 Nomenclature History

Previous Names

madh7
fj60c10
wu:fj60c10

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription, DNA-templated and transforming growth factor beta receptor signaling pathway. Predicted to localize to cytoplasm; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Is expressed in several structures, including axis; ectoderm; immature eye; midbrain neural tube; and nervous system. Orthologous to human SMAD7 (SMAD family member 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77461 (1 image)
eu607 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smad7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Colorectal cancer, susceptibility to, 3}	612229

Associated With smad7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001132	SMAD domain, Dwarfin-type
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR013019	MAD homology, MH1
Family	IPR013790	Dwarfin
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036578	SMAD MH1 domain superfamily