Gene

smad7

ID
ZDB-GENE-030128-3
Name
SMAD family member 7
Symbol
smad7 Nomenclature History
Previous Names
  • madh7
  • fj60c10
  • wu:fj60c10
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; I-SMAD binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to cytoplasm and heteromeric SMAD protein complex. Is expressed in several structures, including axis; ectoderm; immature eye; midbrain neural tube; and nervous system. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 9 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smad7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Colorectal cancer, susceptibility to, 3} 612229
Associated With smad7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001132 SMAD domain, Dwarfin-type
Domain IPR003619 MAD homology 1, Dwarfin-type
Domain IPR013019 MAD homology, MH1
Family IPR013790 Dwarfin
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036578 SMAD MH1 domain superfamily
Domain Details Per Protein
Protein Length Dwarfin MAD homology 1, Dwarfin-type MAD homology, MH1 SMAD domain, Dwarfin-type SMAD/FHA domain superfamily SMAD-like domain superfamily SMAD MH1 domain superfamily
UniProtKB:I3ISV6 179
UniProtKB:Q8AWR7 372
UniProtKB:Q6NZT3 372
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations