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Gene

glud1a

ID
ZDB-GENE-030114-2
Name
glutamate dehydrogenase 1a
Symbol
glud1a Nomenclature History
Previous Names
  • glud1
  • cb622 (1)
  • wu:fc33g09
  • wu:fc66a10
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to act upstream of or within cellular amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; periderm; and pronephros. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glud1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hyperinsulinemic hypoglycemia 6 Alliance Hyperinsulinism-hyperammonemia syndrome 606762
Associated With glud1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR033524 Leu/Phe/Val dehydrogenases active site
Domain IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
Domain IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
Domain IPR033922 NAD(P) binding domain of glutamate dehydrogenase
Family IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Glutamate/phenylalanine/leucine/valine dehydrogenase Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain Leu/Phe/Val dehydrogenases active site NAD(P) binding domain of glutamate dehydrogenase NAD(P)-binding domain superfamily
UniProtKB:B8A4B0 544
UniProtKB:Q6NZ29 544
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations