Gene
igfbp1a
- ID
- ZDB-GENE-021231-1
- Name
- insulin-like growth factor binding protein 1a
- Symbol
- igfbp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in negative regulation of cell population proliferation; regeneration; and response to hypoxia. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in diabetic angiopathy. Is expressed in several structures, including adaxial cell; brain; cardiovascular system; digestive system; and retina. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb656 (33 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Family | IPR022321 | Insulin-like growth factor-binding protein family 1-6, chordata |
| Family | IPR022322 | Insulin-like growth factor-binding protein 1 |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor-binding protein 1 | Insulin-like growth factor-binding protein family 1-6, chordata | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8JHX6
|
262 | |||||||
|
UniProtKB:Q90YJ7
|
262 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp1a-202
(1)
|
Ensembl | 1,773 nt | ||
| ncRNA |
igfbp1a-002
(1)
|
Ensembl | 839 nt |
Interactions and Pathways
No data available
Plasmids