Gene
dmrt3a
- ID
- ZDB-GENE-021220-3
- Name
- doublesex and mab-3 related transcription factor 3a
- Symbol
- dmrt3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within swimming behavior. Predicted to be active in nucleus. Is expressed in nervous system; neural tube; and reproductive system. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101766 (12 images)
- eu876 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dmrt3a | Del Pozo Cano et al., 2020 | |
| CRISPR2-dmrt3a | Wang et al., 2023 | |
| MO1-dmrt3a | N/A | Del Pozo Cano et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DM DNA-binding domain | DM DNA-binding domain superfamily | DMRTA motif | DMRT family | UBA-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:P83758 | InterPro | 448 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dmrt3a-201
(1)
|
Ensembl | 1,920 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(dmrt3a:GAL4FF) |
|
| 1 | (7) | |
| TgBAC(dmrt3a-hsp70l:GFP) |
|
| 1 | (4) | |
| TgBAC(dmrt3a:LOXP-RFP-LOXP-GFP) |
|
| 1 | (2) | |
| Tg(dmrt3a:Cre) |
|
| 1 | Satou et al., 2020 | |
| Tg(dmrt3a:GAL4) |
|
| 1 | (4) | |
| Tg(dmrt3a:LOXP-DsRed-LOXP-DipTox) |
|
| 1 | (2) | |
| Tg(dmrt3a:TETA) |
|
| 1 | Uemura et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-31E5 | ZFIN Curated Data | |
| Encodes | EST | eu876 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:101766 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005779 (1) | 1920 nt | ||
| Genomic | GenBank:BX255951 (1) | 171425 nt | ||
| Polypeptide | UniProtKB:P83758 (1) | 448 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Wang, X., Yue, M., Cheung, J.P.Y., Cheung, P.W.H., Fan, Y., Wu, M., Wang, X., Zhao, S., Khanshour, A.M., Rios, J.J., Chen, Z., Wang, X., Tu, W., Chan, D., Yuan, Q., Qin, D., Qiu, G., Wu, Z., Zhang, J., Ikegawa, S., Wu, N., Wise, C.A., Hu, Y., Luk, K.D.K., Song, Y.Q., Gao, B. (2023) Impaired glycine neurotransmission causes adolescent idiopathic scoliosis. The Journal of Clinical Investigation. 134(2):
- Habicher, J., Manuel, R., Pedroni, A., Ferebee, C., Ampatzis, K., Boije, H. (2022) A new transgenic reporter line reveals expression of protocadherin 9 at a cellular level within the zebrafish central nervous system. Gene expression patterns : GEP. 44:119246
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Del Pozo Cano, A., Manuel, R., Iglesias Gonzalez, A.B., Koning, H., Habicher, J., Zhang, H., Allalou, A., Kullander, K., Boije, H. (2020) Behavioural characterization of dmrt3a mutant zebrafish reveals crucial aspects of vertebrate locomotion through phenotypes related to acceleration. eNeuro. 7(3):
- Satou, C., Sugioka, T., Uemura, Y., Shimazaki, T., Zmarz, P., Kimura, Y., Higashijima, S.I. (2020) Functional Diversity of Glycinergic Commissural Inhibitory Neurons in Larval Zebrafish. Cell Reports. 30:3036-3050.e4
- Uemura, Y., Kato, K., Kawakami, K., Kimura, Y., Oda, Y., Higashijima, S.I. (2020) Neuronal circuits that control rhythmic pectoral fin movements in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(35):6678-6690
- Gerber, V., Yang, L., Takamiya, M., Ribes, V., Gourain, V., Peravali, R., Stegmaier, J., Mikut, R., Reischl, M., Ferg, M., Rastegar, S., Strähle, U. (2019) The HMG box transcription factors Sox1a and b specify a new class of glycinergic interneurons in the spinal cord of zebrafish embryos. Development (Cambridge, England). 146(4):
- Kim, O.T.P., Nguyen, P.T., Shoguchi, E., Hisata, K., Vo, T.T.B., Inoue, J., Shinzato, C., Le, B.T.N., Nishitsuji, K., Kanda, M., Nguyen, V.H., Nong, H.V., Satoh, N. (2018) A draft genome of the striped catfish, Pangasianodon hypophthalmus, for comparative analysis of genes relevant to development and a resource for aquaculture improvement. BMC Genomics. 19:733
- Hensley, M.R., Cui, Z., Chua, R.F., Simpson, S., Shammas, N.L., Yang, J.Y., Leung, Y.F., Zhang, G. (2016) Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports. 6:27816
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