Gene
msna
- ID
- ZDB-GENE-021211-2
- Name
- moesin a
- Symbol
- msna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and cell adhesion molecule binding activity. Acts upstream of or within blood vessel lumenization and endoderm development. Predicted to be located in anchoring junction. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Is expressed in several structures, including cardiovascular system; gut; hypochord; nervous system; and swim bladder bud. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2457 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 50 | Alliance | Immunodeficiency 50 | 300988 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019747 | FERM conserved site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR011259 | Ezrin/radixin/moesin, C-terminal |
| Domain | IPR018979 | FERM, N-terminal |
| Domain | IPR018980 | FERM, C-terminal PH-like domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR041789 | ERM family, FERM domain C-lobe |
| Domain | IPR046810 | Ezrin/radixin/moesin, alpha-helical domain |
| Family | IPR000798 | Ezrin/radixin/moesin-like |
| Family | IPR011174 | Ezrin/radixin/moesin |
| Homologous_superfamily | IPR008954 | Moesin tail domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | ERM family, FERM domain C-lobe | Ezrin/radixin/moesin | Ezrin/radixin/moesin, alpha-helical domain | Ezrin/radixin/moesin, C-terminal | Ezrin/radixin/moesin-like | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | Moesin tail domain superfamily | PH-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66I42 | InterPro | 579 | ||||||||||||||||
| UniProtKB:A0A8M3AZE1 | InterPro | 443 | ||||||||||||||||
| UniProtKB:A0A8M3B2A2 | InterPro | 568 |
Interactions and Pathways
No data available
Plasmids