Gene
mtx1b
- ID
- ZDB-GENE-021210-1
- Name
- metaxin 1b
- Symbol
- mtx1b Nomenclature History
- Previous Names
-
- mtx1
- zgc:101675
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be involved in mitochondrion organization. Predicted to act upstream of or within protein transport. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; immature eye; myotome; and optic tectum. Orthologous to human MTX1 (metaxin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150246 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36839 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019564 | Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain |
| Domain | IPR033468 | Metaxin, glutathione S-transferase domain |
| Family | IPR017410 | Mitochondrial outer membrane transport complex protein Metaxin 1/3 |
| Family | IPR040079 | Glutathione transferase family |
| Family | IPR050931 | Mitochondrial Protein Transport Metaxin |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal domain superfamily | Glutathione transferase family | Metaxin, glutathione S-transferase domain | Mitochondrial outer membrane transport complex protein Metaxin 1/3 | Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain | Mitochondrial Protein Transport Metaxin |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RKQ2 | InterPro | 317 | ||||||
| UniProtKB:A0A8M9PR98 | InterPro | 317 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278C2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-81H8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7150246 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:101675 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007280 (1) | 1274 nt | ||
| Genomic | GenBank:BX927224 (2) | 79151 nt | ||
| Polypeptide | UniProtKB:A0A8M9PR98 (1) | 317 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- McKenzie, P., Chadalavada, S.C., Bohrer, J., and Adams, J.C. (2006) Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation. BMC Evolutionary Biology. 6(1):33
- Adolph, K.W. (2004) The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Gene. 330:67-73
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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