Gene
sdc2
- ID
- ZDB-GENE-021206-3
- Name
- syndecan 2
- Symbol
- sdc2 Nomenclature History
- Previous Names
-
- cb440 (1)
- zgc:103676
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including Kupffer's vesicle development; circulatory system development; and epiboly involved in gastrulation with mouth forming second. Predicted to be located in membrane. Predicted to be active in cell surface. Is expressed in several structures, including cardiovascular system; digestive system; endoderm; fin; and nervous system. Human ortholog(s) of this gene implicated in cleft lip and cleft palate. Orthologous to human SDC2 (syndecan 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb440 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-sdc2 | N/A | (3) |
| MO2-sdc2 | N/A | Chen et al., 2004 |
| MO3-sdc2 | N/A | (3) |
| MO4-sdc2 | N/A | (2) |
| MO5-sdc2 | N/A | (2) |
| MO6-sdc2 | N/A | Lambaerts et al., 2012 |
| MO7-sdc2 | N/A | Arrington et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Neurexin/syndecan/glycophorin C | Syndecan | Syndecan, conserved site | Syndecan/Neurexin domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q66I66 | InterPro | 208 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-128K20 | ZFIN Curated Data | |
| Contained in | BAC | CH73-345A19 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-65B8 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-244I5 | ZFIN Curated Data | |
| Encodes | EST | cb440 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:103676 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173223 (1) | 993 nt | ||
| Genomic | GenBank:CU138512 (1) | 100533 nt | ||
| Polypeptide | UniProtKB:Q66I66 (1) | 208 aa |
- Keil, S., Gupta, M., Brand, M., Knopf, F. (2021) Heparan sulfate proteoglycan expression in the regenerating zebrafish fin. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(9):1368-1380
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Li, J., Ling, Y., Huang, W., Sun, L., Li, Y., Wang, C., Zhang, Y., Wang, X., Dahlgren, R.A., Wang, H. (2018) Regulatory mechanisms of miR-96 and miR-184 abnormal expressions on otic vesicle development of zebrafish following exposure to β-diketone antibiotics. Chemosphere. 214:228-238
- Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
- Luo, N., Li, H., Xiang, B., Qiao, L., He, J., Ji, Y., Liu, Y., Li, S., Lu, R., Li, Y., Meng, W., Wu, Y., Xu, H., Mo, X. (2016) Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis. Scientific Reports. 6:25300
- Müller-Deile, J., Gellrich, F., Schenk, H., Schroder, P., Nyström, J., Lorenzen, J., Haller, H., Schiffer, M. (2016) Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 40:819-830
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Arrington, C.B., Peterson, A.G., and Yost, H.J. (2013) Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry. Development (Cambridge, England). 140(19):4102-4109
- Hofmeister, W., Devine, C.A., and Key, B. (2013) Distinct expression patterns of syndecans in the embryonic zebrafish brain. Gene expression patterns : GEP. 13(3-4):126-32
- Samson, S.C., Ferrer, T., Jou, C.J., Sachse, F.B., Shankaran, S.S., Shaw, R.M., Chi, N.C., Tristani-Firouzi, M., and Yost, H.J. (2013) 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biology. 11(12):e1001727
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