ZFIN is now using GRCz12tu for Genomic Data
Gene
farsb
- ID
- ZDB-GENE-021206-2
- Name
- phenylalanyl-tRNA synthetase subunit beta
- Symbol
- farsb Nomenclature History
- Previous Names
-
- farsl
- cb428 (1)
- zgc:92055
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including ATP binding activity; aminoacyl-tRNA ligase activity; and magnesium ion binding activity. Predicted to contribute to phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; musculature system; and nervous system. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb428 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Rajab interstitial lung disease with brain calcifications 1 | 613658 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005146 | B3/B4 tRNA-binding domain |
| Domain | IPR005147 | tRNA synthetase, B5-domain |
| Domain | IPR040659 | Phenylalanine--tRNA ligase beta subunit, B1 domain |
| Domain | IPR041616 | Phenylalanyl tRNA synthetase beta chain, core domain |
| Family | IPR004531 | Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archaeal/eukaryotic type |
| Family | IPR045060 | Phenylalanine-tRNA ligase, class IIc, beta subunit |
| Homologous_superfamily | IPR009061 | Putative DNA-binding domain superfamily |
| Homologous_superfamily | IPR020825 | Phenylalanyl-tRNA synthetase-like, B3/B4 |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Additional Resources | Length | B3/B4 tRNA-binding domain | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Phenylalanine--tRNA ligase beta subunit, B1 domain | Phenylalanine-tRNA ligase, class IIc, beta subunit | Phenylalanyl tRNA synthetase beta chain, core domain | Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archaeal/eukaryotic type | Phenylalanyl-tRNA synthetase-like, B3/B4 | Putative DNA-binding domain superfamily | tRNA synthetase, B5-domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RKM6 | InterPro | 590 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers