Gene
bckdk
- ID
- ZDB-GENE-021204-1
- Name
- branched chain ketoacid dehydrogenase kinase
- Symbol
- bckdk Nomenclature History
- Previous Names
-
- cb233 (1)
- wu:fa04g07
- wu:fb80b08
- zgc:55984
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in protein phosphorylation and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including midbrain neural keel; midbrain neural rod; neural plate; pancreatic system; and primary neurons. Human ortholog(s) of this gene implicated in branched-chain keto acid dehydrogenase kinase deficiency. Orthologous to human BCKDK (branched chain keto acid dehydrogenase kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb233 (13 images)
- IMAGE:7148750 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| branched-chain keto acid dehydrogenase kinase deficiency | Alliance | Branched-chain keto acid dehydrogenase kinase deficiency | 614923 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR004358 | Signal transduction histidine kinase-related protein, C-terminal |
| Domain | IPR005467 | Histidine kinase domain |
| Domain | IPR018955 | Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal |
| Family | IPR039028 | PDK/BCKDK protein kinase |
| Homologous_superfamily | IPR036784 | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily | Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal | Histidine kinase domain | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | PDK/BCKDK protein kinase | Signal transduction histidine kinase-related protein, C-terminal |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B0R159
|
428 |
Interactions and Pathways
No data available
Plasmids
No data available