Gene

c7b

ID
ZDB-GENE-021120-1
Name
complement component 7b
Symbol
c7b Nomenclature History
Previous Names
  • c7 (1)
  • C7-1 (1)
  • cb349 (1)
  • si:dkey-246j23.5
  • wu:fa01f03
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to be involved in complement activation, classical pathway; cytolysis; and innate immune response. Predicted to localize to extracellular region and membrane attack complex. Is expressed in central nervous system and yolk syncytial layer. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c7b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
complement component 7 deficiency Alliance C7 deficiency 610102
Associated With c7b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR003884 Factor I / membrane attack complex
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Domain IPR040729 Kazal-type serine protease inhibitor domain
Domain IPR048825 Complement component C7, Kazal domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement component C7, Kazal domain Factor I / membrane attack complex Kazal-type serine protease inhibitor domain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A repeat Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M9PWA7 833
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA c7b-201 (1) Ensembl 2,612 nt
mRNA c7b-202 (1) Ensembl 2,569 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations