ZFIN ID: ZDB-GENE-021119-1
Gene Name: dopamine receptor D3
Gene Symbol: drd3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and regulation of ion transport. Predicted to localize to integral component of plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3).
Genome Resources: Alliance (1),  Gene:282554 (1),  Ensembl(GRCz11):ENSDARG00000032131 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6765 Point Mutation Unknown Premature Stop ENU
sa15862 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-drd3
    3
    CRISPR2-drd3
    1
    CRISPR3-drd3
    1
    TALEN1-drd3
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH drd3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    essential tremor 1 Alliance {Essential tremor, hereditary, 1} 190300
    schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
    DISEASE ASSOCIATED WITH drd3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA drd3-201 (1)    Ensembl 1400
    drd3-202 (1)    Ensembl 2285
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM drd3 No data available
    MARKER RELATIONSHIPS
    drd3 Contained in: [BAC] CH73-50O14 (1), CH211-72H10 (1)
    drd3 Encodes: [cDNA] MGC:92896 (1), MGC:192815 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_183067 (1) 1400 nt
    Genomic GenBank:CT956069 (1) 137539 nt
    Select Tool
    Polypeptide UniProtKB:F1QG18 (1) 472 aa
    Sequence Information (all 23)
    ORTHOLOGY for drd3 ( Chr: 24 )
    CITATIONS (51)