ZFIN is now using GRCz12tu for Genomic Data
Gene
drd3
- ID
- ZDB-GENE-021119-1
- Name
- dopamine receptor D3
- Symbol
- drd3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway and negative regulation of glutamatergic synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in essential tremor; essential tremor 1; schizophrenia; and toxic encephalopathy. Orthologous to human DRD3 (dopamine receptor D3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential tremor 1 | Alliance | {Essential tremor, hereditary, 1} | 190300 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:Q8AWE1 | InterPro | 454 | |||
| UniProtKB:F1QG18 | InterPro | 472 | |||
| UniProtKB:A0A8M9PTW6 | InterPro | 467 | |||
| UniProtKB:A0AB32TCS3 | InterPro | 448 | |||
| UniProtKB:A0AC58IPC9 | InterPro | 268 | |||
| UniProtKB:A0AC58IPD9 | InterPro | 443 | |||
| UniProtKB:A0AC58IPE2 | InterPro | 273 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers