ZFIN ID: ZDB-GENE-021115-5
Gene Name: v-ets avian erythroblastosis virus E26 oncogene homolog 1
Gene Symbol: ets1    Nomenclature History

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Previous Names: ets1a, cb516 (1), id:ibd1116, zgc:110573

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in blood vessel morphogenesis. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is expressed in several structures, including cardiovascular system; germ ring; hematopoietic system; mesoderm; and nervous system. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor).
Genome Resources: Alliance (1),  Gene:280651 (1),  Ensembl(GRCz11):ENSDARG00000024431 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32223 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43179 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um206 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ets1 1
    MO1-ets1 N/A 1
    MO2-ets1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ets1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ets1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000418 Ets domain
    Domain IPR003118 Pointed domain
    Domain IPR041886 Protein C-ets-1, pointed domain
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM ets1 No data available
    MARKER RELATIONSHIPS
    ets1 Encodes: [EST] cb516 (1) (order this), fb78f02 (1) (order this), ibd1116
    [cDNA] MGC:110573, MGC:193078 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017558 (1) 1594 nt
    Genomic GenBank:CABZ01069597 (1) 34916 nt
    Select Tool
    Polypeptide UniProtKB:A0A076VF89 (1) 432 aa
    Sequence Information (all 33)
    ORTHOLOGY for ets1 ( Chr: 18 )
    CITATIONS (48)