Gene
cdon
- ID
- ZDB-GENE-021115-4
- Name
- cell adhesion associated, oncogene regulated
- Symbol
- cdon Nomenclature History
- Previous Names
-
- cb507 (1)
- wu:fa10c03
- wu:fb94b11
- zgc:158240
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Acts upstream of or within negative regulation of smoothened signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural plate; and neural tube. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb507 (31 images)
- IMAGE:7156053 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cdz1 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| co1019 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| co1023 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| la020461Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027963Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa10351 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23371 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36719 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36720 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43164 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 11 | Alliance | Holoprosencephaly 11 | 614226 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1L8D0 | InterPro | 1125 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-203F8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-79N12 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-68F4 | ZFIN Curated Data | |
| Encodes | EST | cb507 | Thisse et al., 2001 | |
| Encodes | EST | fa10c03 | ||
| Encodes | EST | fb94b11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7156053 | Thisse et al., 2004 | |
| Encodes | cDNA | cssl:d145 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:158240 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001081628 (1) | 4158 nt | ||
| Genomic | GenBank:BX005312 | 207484 nt | ||
| Polypeptide | UniProtKB:Q1L8D0 (1) | 1125 aa |
- Deng, Z., Ran, Q., Chang, W., Li, C., Li, B., Huang, S., Huang, J., Zhang, K., Li, Y., Liu, X., Liang, Y., Guo, Z., Huang, S. (2024) Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis. Frontiers in cell and developmental biology. 12:14297821429782
- Lencer, E., Rains, A., Binne, E., Prekeris, R., Artinger, K. (2023) Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish. Development (Cambridge, England). 150(14):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Powell, D.R., Williams, J.S., Hernandez-Lagunas, L., Salcedo, E., O'Brien, J.H., Bruk Artinger, K. (2015) Cdon promotes neural crest migration by regulating N-cadherin localization. Developmental Biology. 407(2):289-99
- Cardozo, M.J., Sánchez-Arrones, L., Sandonis, A., Sánchez-Camacho, C., Gestri, G., Wilson, S.W., Guerrero, I., Bovolenta, P. (2014) Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Nature communications. 5:4272
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, X., Zhao, Z., Muller, J., Iyu, A., Khng, A.J., Guccione, E., Ruan, Y., and Ingham, P.W. (2013) Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biology Open. 2(11):1203-1213
- Bergeron, S.A., Tyurina, O.V., Miller, E., Bagas, A., and Karlstrom, R.O. (2011) Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development (Cambridge, England). 138(1):75-85
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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